N-(Azido-PEG3)-N-bis(PEG4-acid)

Name: N-(Azido-PEG3)-N-bis(PEG4-acid)
Brand: MedChemExpress
SKU: HY-140518
Rating: 4.5 (1 reviews)

製品番号: HY-140518 純度: 98.0%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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N-(Azido-PEG3)-N-bis(PEG4-acid) 構造式

CAS 番号 : 2112731-54-9

容量	価格（税別）	在庫状況	数量
50 mg	$195	在庫あり	Estimated Time of Arrival: December 31
100 mg	$315	在庫あり	Estimated Time of Arrival: December 31
250 mg	$630	在庫あり	Estimated Time of Arrival: December 31
500 mg	$1060	在庫あり	Estimated Time of Arrival: December 31
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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

714.80

分子式

C₃₀H₅₈N₄O₁₅

CAS 番号

2112731-54-9

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (270 KB) SDS (393 KB)

COA (252 KB) HNMR (281 KB) MS (71 KB)

取扱説明書 (2659 KB)

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]