2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. JAK Apoptosis
  4. NSC114792

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5.

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NSC114792

NSC114792 화학구조

CAS No. : 17392-79-9

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제품 설명

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5[1].

IC50 & Target[1]

JAK3

 

In Vitro

NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) inhibits BaF3-JAK3V674A and BKO84 cell viability in a time and dose-dependent manner[1].
NSC114792 (0, 5, 10, 20 µM) decreases the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner[1].
NSC114792 (0, 5, 10, 20 µM; 72 h) induces apoptosis in a dose-dependent manner in L540 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC114792 Related Antibodies

Cell Viability Assay[1]

Cell Line: L540, HDLM-2, MDA-MB-468, DU145 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 0, 24, 48, 72 h
Result: Inhibited cell viability in a time and dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BKO84 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time:
Result: Decreased the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: L540 cells
Concentration: 0, 10, 20 µM
Incubation Time: 72 h
Result: Induced apoptosis and increased the expression of cleaved PARP and cleaved Capase-3, decreased the protein expression of Bcl-2, Bcl-Xl, Mcl-1, Survivin in a dose-dependent manner.
분자량

464.62

화학식

C26H32N4O2S
CAS No.
SMILES

C[C@@]12[C@@H](C(CN3C=NC4=C3N=CNC4=S)=O)CC[C@@]1([H])[C@]5([H])CCC6=CC(CC[C@]6(C)[C@@]5([H])CC2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Keywords:

NSC11479217392-79-9NSC 114792NSC-114792JAKApoptosisJanus kinaseBKO84 cellsL540 cellsapoptosisp-JAK3p-STAT5Inhibitorinhibitorinhibit

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상품명:
NSC114792
Cat. No.:
HY-122101
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