1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Pizotifen malate

Pizotifen malate (Synonyms: Pizotyline malate; BC-105 malate)

Cat. No.: HY-B0115A
Handling Instructions

Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

For research use only. We do not sell to patients.

Pizotifen malate Chemical Structure

Pizotifen malate Chemical Structure

CAS No. : 5189-11-7

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Description

Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

IC50 & Target

5-HT2A Receptor

 

5-HT1C Receptor

 

In Vitro

Pizotifen malate (BC-105 malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site[1]. Pizotifen is an antidepresent 5-HT2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

429.53

Formula

C₂₃H₂₇NO₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[3]

Mice[3]
Pizotifen malate is administered orally to three groups of Swiss mice in doses of 0.24, 0.6 and 1.2 mg/kg from day 4 to day 16 of gestation. The control group is treated with distilled water. On day 19 of gestation, the mice are sacrificed and cytogenetical examination and uterine content (number of live, abnormal and dead fetuses as well as the number of implantations, resorptions) are determined. The live fetuses were inspected for external, visceral and skeletal malformations[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Pizotifen malate
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HY-B0115A
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