1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Pizotifen

Pizotifen (Synonyms: BC-105; Pizotyline)

Cat. No.: HY-B0115 Purity: 99.65%
Handling Instructions

Pizotifen (BC-105) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

For research use only. We do not sell to patients.

Pizotifen Chemical Structure

Pizotifen Chemical Structure

CAS No. : 15574-96-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

Pizotifen (BC-105) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

IC50 & Target[1][2]

5-HT2A Receptor

 

5-HT1C Receptor

 

In Vitro

Pizotifen (BC-105) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site[1]. Pizotifen is an antidepresent 5-HT2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation[2].

In Vivo

The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen (BC-105); the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen (BC-105) maleate, the mitotic indices are lower than in the control group[3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (67.70 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3848 mL 16.9239 mL 33.8478 mL
5 mM 0.6770 mL 3.3848 mL 6.7696 mL
10 mM 0.3385 mL 1.6924 mL 3.3848 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (6.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

295.44

Formula

C₁₉H₂₁NS

CAS No.

15574-96-6

SMILES

CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Pizotifen
Cat. No.:
HY-B0115
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Pizotifen

Cat. No.: HY-B0115