Akt1 in endothelial cell and angiogenesis

  • Cell Cycle. 2006 Mar;5(5):512-8. doi: 10.4161/cc.5.5.2538.
Payaningal R Somanath  1 ,  Olga V Razorenova ,  Juhua Chen ,  Tatiana V Byzova
Affiliations
  • 1. Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
PMID: 16552185 DOI: 10.4161/cc.5.5.2538
Abstract

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, Apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as Cancer and ischemic injury.

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