The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain

1. Two week chronic administration of trimipramine increased the brain concentration and metabolism of dopamine and 5-hydroxytryptamine. 2. The treatment also produced a reduction in dopamine D2 and 5-hydroxytryptamine 5-HT2 receptors but no change in tryptamine binding was observed. 3. These findings suggest that trimipramine induces adaptive changes in dopamine and 5-hydroxytryptamine neurotransmission.