Trimipramine maleate (Standard)
Trimipramine (maleate) (Standard) is the analytical standard of Trimipramine (maleate). This product is intended for research and analytical applications. Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 521-78-8
- Formula: C24H30N2O4
- Molecular Weight:410.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Trimipramine maleate
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Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 521-78-8
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Molecular Weight 410.51
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Formula C24H30N2O4
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SMILES
CC(CN(C)C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9;231(2):223-9. [Content Brief]
[2]. Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep. 217(2):289-95. [Content Brief]
[3]. Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990;21(5):759-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trimipramine maleate (Standard) Related Classifications
HY-B1213R Related Classifications
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- Trimipramine maleate (Standard)
- 521-78-8
- Reference Standards
- 5-HT Receptor
- Bacterial
- antidepressants
- 5-HT
- 5-hydroxytryptamine
- serotonin
- 5-HTlc receptors
- 5-HTIA receptors
- dopamine
- DA
- DA D2 receptor
- 5-HT1C
- 5-HT2
- 5-HT1A
- anxiolytic
- neurological disease
- noradrenaline
- hNAT
- hSERT
- hDAT
- human organic cation transporters
- hOCT1
- hOCT2
- hOCT3
- Inhibitor
- inhibitor
- inhibit