1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

Benztropine mesylate (Synonyms: Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate)

Cat. No.: HY-B0520A Purity: 98.92%
Handling Instructions

Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.

For research use only. We do not sell to patients.

Benztropine mesylate Chemical Structure

Benztropine mesylate Chemical Structure

CAS No. : 132-17-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Top Publications Citing Use of Products

    Benztropine mesylate purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease. Target: mAChR Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease. It may also be used to treat extrapyramidal reactions, such as dystonia and Parkinsonism, caused by antipsychotics. Symptoms of Parkinson's disease and extrapyramidal reactions arise from decreases in dopaminergic activity which creates an imbalance between dopaminergic and cholinergic activity. Anticholinergic therapy is thought to aid in restoring this balance leading to relief of symptoms. In addition to its anticholinergic effects, benztropine also inhibits the reuptake of dopamine at nerve terminals via the dopamine transporter. Benzotropine also produces antagonistic effects at the histamine H1 receptor [1, 2]. Benztropine (BZT) and its analogues inhibit dopamine uptake and bind with moderate to high affinity to the dopamine transporter (DAT). BZT analogues also exhibit varied binding affinities for muscarinic M(1) and histamine H(1) receptors. The BZT analogues showed a wide range of histamine H(1) receptor (K(i)=16-37,600 nM) and DAT (K(i)=8.5-6370 nM) binding affinities [3].

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 200 mg/mL (495.61 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4781 mL 12.3903 mL 24.7807 mL
    5 mM 0.4956 mL 2.4781 mL 4.9561 mL
    10 mM 0.2478 mL 1.2390 mL 2.4781 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    403.54

    Formula

    C₂₂H₂₉NO₄S

    CAS No.

    132-17-2

    SMILES

    CN1[[email protected]]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[[email protected]@H]1CC2.CS(=O)(O)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 98.92%

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    Product Name:
    Benztropine mesylate
    Cat. No.:
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    Benztropine mesylate

    Cat. No.: HY-B0520A