1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Dopamine Receptor
    mAChR
    Histamine Receptor
  3. Benztropine mesylate

Benztropine mesylate (Synonyms: Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate)

Cat. No.: HY-B0520A Purity: 99.86%
Handling Instructions

Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

For research use only. We do not sell to patients.

Benztropine mesylate Chemical Structure

Benztropine mesylate Chemical Structure

CAS No. : 132-17-2

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Benztropine mesylate purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.
    • Biological Activity

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    Description

    Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[1][2].

    IC50 & Target[1]

    Human D2 Receptor

     

    In Vitro

    Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1].
    Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors[1].
    Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MDA-MB-231 cells
    Concentration: 0.1 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
    Incubation Time: 72 hours
    Result: Inhibited the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM.
    In Vivo

    Benztropine mesylate (1.5 mg/kg; daily; for 3 weeks; Balb/c mice) treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    403.54

    Formula

    C₂₂H₂₉NO₄S

    CAS No.

    132-17-2

    SMILES

    CN1[[email protected]]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[[email protected]@H]1CC2.CS(=O)(O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (247.81 mM; Need ultrasonic)

    DMSO : 100 mg/mL (247.81 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4781 mL 12.3903 mL 24.7807 mL
    5 mM 0.4956 mL 2.4781 mL 4.9561 mL
    10 mM 0.2478 mL 1.2390 mL 2.4781 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

    • 4.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (247.81 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.86%

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    Keywords:

    BenztropineBenzatropineBenzotropineDopamine ReceptormAChRHistamine ReceptorMuscarinic acetylcholine receptorParkinson'sdiseaseanticholinergicdopaminetransporteranti-histamineInhibitorinhibitorinhibit

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    Product Name:
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