Trimipramine (Standard)
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 739-71-9
- Formule: C20H26N2
- Masse moléculaire:294.43
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureté et documentation
-
Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 739-71-9
-
Masse moléculaire 294.43
-
Formule C20H26N2
-
SMILES
CC(CN1C2=CC=CC=C2CCC3=C1C=CC=C3)CN(C)C
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9. 231(2):223-9. [Content Brief]
[2]. Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep. 217(2):289-95. [Content Brief]
[3]. Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990. 21(5):759-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trimipramine (Standard) Related Classifications
HY-B1213AR Related Classifications
Powered by Bioz
Keywords
- Trimipramine (Standard)
- 739-71-9
- Reference Standards
- 5-HT Receptor
- Bacterial
- antidepressants
- 5-HT
- 5-hydroxytryptamine
- serotonin
- 5-HTlc receptors
- 5-HTIA receptors
- dopamine
- DA
- DA D2 receptor
- 5-HT1C
- 5-HT2
- 5-HT1A
- anxiolytic
- neurological disease
- noradrenaline
- hNAT
- hSERT
- hDAT
- human organic cation transporters
- hOCT1
- hOCT2
- hOCT3
- Inhibitor
- inhibitor
- inhibit