1. Cytoskeleton
  2. Integrin
  3. RWJ 50271

RWJ 50271 

Cat. No.: HY-110086 Purity: >99.0%
Handling Instructions

RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells).

For research use only. We do not sell to patients.

RWJ 50271 Chemical Structure

RWJ 50271 Chemical Structure

CAS No. : 162112-37-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 485 In-stock
Estimated Time of Arrival: December 31
5 mg USD 485 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

IC50 & Target

IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]

Molecular Weight

410.41

Formula

C₁₈H₁₇F₃N₄O₂S

CAS No.

162112-37-0

SMILES

CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (609.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4366 mL 12.1829 mL 24.3659 mL
5 mM 0.4873 mL 2.4366 mL 4.8732 mL
10 mM 0.2437 mL 1.2183 mL 2.4366 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

RWJ 50271RWJ50271RWJ-50271IntegrinInhibitorinhibitorinhibit

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Product Name:
RWJ 50271
Cat. No.:
HY-110086
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