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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
αKG
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "αKG" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: Disodium (R)-2-hydroxyglutarate
4
4 Cited Publications
Cat. No.: HY-113038
CAS No.: 13095-47-1
Synonyms: (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid
Cat. No.: HY-P3263
CAS No.: 39346-34-4
Synonyms: L-Glutamate oxidase
Target:
Research Areas:
Glutamate oxidase (L-Glutamate oxidase) is a FAD-dependent oxidase with high substrate selectivity. Glutamate oxidase catalyzes the oxidative deamination of L-glutamate using O2 to produce α-ketoglutarate (α-KG), NH3, and H2O2. Glutamate oxidase is applicable to research related to the biocatalytic production of α-KG and the analytical detection of L-glutamate .
Target:
Research Areas:
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .
Cat. No.: HY-W654003
Synonyms: Disodium (R)-2-hydroxyglutarate-d5
Cat. No.: HY-169061
Research Areas:
WQQ-345 is an orally active BCAT1 inhibitor with an IC50 values of 10.8 mM. WQQ-345 reduces cellular α-KG levels, upregulating H3K27me3 expression, decreasing glycolytic enzyme expression, and impairing glycolysis activity. WQQ-345 reduces colony formation, suppresses growth of BCAT1-high TKI-resistant lung cancer cells. WQQ-345 exerts in vitro and in vivo antitumor activity. WQQ-345 can be used for the research of TKI-resistant non-small cell lung cancer and TKI-resistant lung cancer .
Cat. No.: HY-121916
CAS No.: 1355446-05-7
Target:
Research Areas:
ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer .
Cat. No.: HY-W779800
CAS No.: 1648909-80-1
Cat. No.: HY-100542R
CAS No.: 103404-90-6
Synonyms: Disodium (R)-2-hydroxyglutarate (Standard)
Cat. No.: HY-E71609
Target:
Research Areas:
2-Oxoglutarate reductase (EC 1.1.1.399) is an oxidoreductase that catalyzes the reversible interconversion between 2-hydroxyglutarate (2-HG) and 2-oxoglutarate (also known as α-ketoglutarate, α-KG).
Cat. No.: HY-L064
1,810 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.
MCE owns a unique collection of 1,810 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
