Search Result

Results for "

β5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) Akt (1) AMPK (1) Amyloid-β (1) Apoptosis (7) Autophagy (6) Bacterial (1) Biochemical Assay Reagents (2) Cholinesterase (ChE) (1) Cuproptosis (2) Drug Derivative (7) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) Fluorescent Dye (3) Integrin (17) Interleukin Related (1) Isotope-Labeled Compounds (5) Ligands for Target Protein for PROTAC (1) NF-κB (1) Parasite (3) Peptide-Drug Conjugates (PDCs) (1) PI3K (1) Prostaglandin Receptor (1) PROTACs (2) Proteasome (26) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) TGF-β Receptor (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (3) Endocrinology (2) Infection (6) Inflammation/Immunology (14) Metabolic Disease (3) Neurological Disease (3)

By Targets:

11β-HSD (1)

Akt (1)

AMPK (1)

Amyloid-β (1)

Apoptosis (7)

Autophagy (6)

Bacterial (1)

Biochemical Assay Reagents (2)

Cholinesterase (ChE) (1)

Cuproptosis (2)

Drug Derivative (7)

Drug Metabolite (1)

E3 Ligase Ligand-Linker Conjugates (1)

Endogenous Metabolite (1)

Fluorescent Dye (3)

Integrin (17)

Interleukin Related (1)

Isotope-Labeled Compounds (5)

Ligands for Target Protein for PROTAC (1)

NF-κB (1)

Parasite (3)

Peptide-Drug Conjugates (PDCs) (1)

PI3K (1)

Prostaglandin Receptor (1)

PROTACs (2)

Proteasome (26)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (2)

TGF-β Receptor (2)

By Research Areas:

Cancer (38)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (6)

Inflammation/Immunology (14)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Bibliotecas de Screening

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-12040

Elesclomol Maximum Cited Publications 115 Publications Verification STA-4783	Reactive Oxygen Species (ROS) Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-10453

Ixazomib 20+ Cited Publications MLN2238	Proteasome Autophagy	Cancer
Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM).

HY-10985

Marizomib 15+ Cited Publications Salinosporamide A; NPI-0052	Proteasome	Cancer
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-16143

Cilengitide TFA 65+ Cited Publications EMD 121974 TFA	Integrin Autophagy	Cancer
Cilengitide is a potent and selective integrin inhibitor for α_vβ₃ and α_vβ₅ receptor, with IC₅₀ values of 4 nM and 79 nM, respectively.

HY-15102

MK-0429 5+ Cited Publications L-000845704	Integrin	Inflammation/Immunology Cancer
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC₅₀ values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively .

HY-12113

Oprozomib 3 Publications Verification ONX 0912; PR-047	Proteasome Autophagy Apoptosis	Cancer
Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC₅₀s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells .

HY-P5133

Synstatin (92-119) 1 Publications Verification SSTN92-119	Integrin	Cancer
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupts the formation of the syndecan-1 : integrin : IGF1R ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma .

HY-D1705

Ac-ANW-AMC	Proteasome	Inflammation/Immunology
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure *β5i* activity (Ex=345 nm, Em=445 nm) .

HY-19307

SB-273005	Integrin Interleukin Related	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
SB-273005 is an orally active non-peptide αvβ3 integrin antagonist with K_i values of 1.2 nM and 0.3 nM for αvβ3 and αvβ5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. ^[5].

HY-19767

GSK 3008348 2 Publications Verification	Integrin TGF-β Receptor	Infection Inflammation/Immunology Cancer
GSK 3008348 is a small molecule antagonist of integrin αvβ6 with IC₅₀ values for αvβ6, αvβ1, αvβ3, αvβ5, and αvβ8 are 1.50, 2.83, 12.53, 4.00, and 2.26 nM, respectively. GSK 3008348 can target the αvβ6 integrin, inhibit TGF-β activation, and thereby alleviate the fibrotic process. GSK 3008348 prevents the binding of the foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor on the surface of host cells, thereby inhibiting the entry of the virus. GSK 3008348 can be used for research on pulmonary fibrosis and various types of cancer .

HY-145363

αvβ5 integrin-IN-1 1 Publications Verification	Integrin	Cancer
αvβ5 integrin-IN-1 (Compound 12) is a selective αvβ5 inhibitor (pIC₅₀ = 8.2). αvβ5 integrin-IN-1 exhibits 800-fold selectivity for αvβ5 versus αvβ3 .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-P0295

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ～5 and ～6.5 μM

HY-130119

Integrin-IN-2	Integrin	Cancer
Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC₅₀ values of 7.8, 8.4, 8.4 and 7.4, respectively .

HY-119037

UK-101	Proteasome Apoptosis	Cancer
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC₅₀ value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC₅₀=15 μM) and β5 subunit (IC₅₀=1 μM), respectivey . UK-101 induces cell apoptosis and can be used for the study of prostate cancer .

HY-111790

M3258 5 Publications Verification	Proteasome Apoptosis	Cancer
M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC₅₀=3.6 nM) and cellular (IC₅₀=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells .

HY-19767A

GSK 3008348 hydrochloride 2 Publications Verification	Integrin TGF-β Receptor	Infection Inflammation/Immunology Cancer
GSK 3008348 hydrochloride is a small molecule antagonist of integrin αvβ6 with IC₅₀ values for αvβ6, αvβ1, αvβ3, αvβ5, and αvβ8 are 1.50, 2.83, 12.53, 4.00, and 2.26 nM, respectively. GSK 3008348 hydrochloride can target the αvβ6 integrin, inhibit TGF-β activation, and thereby alleviate the fibrotic process. GSK 3008348 hydrochloride prevents the binding of the foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor on the surface of host cells, thereby inhibiting the entry of the virus. GSK 3008348 hydrochloride can be used for research on pulmonary fibrosis and various types of cancer .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-19306

SB-267268	Integrin	Cancer
SB-267268 is a selective and nonpeptidic alpha(v)beta3 (αvβ3) and alpha(v)beta5 (αvβ5) integrins antagonist, with K_is of 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively. SB-267268 inhibits human and mouse αvβ3 with IC₅₀s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression .

HY-W010934

3β,5α,6β-Trihydroxycholestane	Biochemical Assay Reagents	Others
3β,5α,6β-Trihydroxycholestane is a steroid that occurs naturally in the body and is also found in certain foods. It belongs to a class of compounds known as cholestanes, which are closely related to the better known cholesterol. This particular compound is formed from cholesterol through a series of enzymatic reactions in the liver and other organs. It has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. Some research suggests that it may also play a role in regulating blood sugar levels and improving insulin sensitivity. Despite these potential benefits, 3β,5α,6β-Trihydroxycholestane is not widely used as a supplement or medicine due to its relatively low content, focus on natural resources and limited research. However, researchers continue to investigate its potential uses and effects on human health.

HY-148732

LU-005i	Proteasome	Inflammation/Immunology
LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC₅₀ = 6.6 nM), selective over β5c subunit (IC₅₀ = 287 nM) .

HY-P10030

DPLG3	Proteasome NF-κB	Inflammation/Immunology
DPLG3 is a specific chymotryptic-like *β5i* subunits inhibitor, with an IC₅₀ of 4.5 nM. DPLG3 inhibits mouse i-20S with IC₅₀ of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research .

HY-D2439

RGD-PEG-Cy3	Fluorescent Dye	Cancer
RGD-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, peptide (RGD) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. RGD is a peptide sequence (CRGDKGPDCiRGD) that binds to αvβ3 and αvβ5 integrin receptors on tumor neovasculogenesis to achieve specific tumor tissue targeting .

HY-127102

GSK3494245 DDD01305143	Parasite Proteasome	Infection
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC₅₀=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC₅₀: purified 26S=13 µM; enriched THP-1 extracts IC₅₀=40µM). GSK3494245 exhibits attractive biological and biosafety properties .

HY-169135

PROTAC 20S proteasome subunit β5 degrader 2	PROTACs Proteasome	Cancer
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC₅₀ of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC₅₀ of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models . (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

HY-P2153

Maraciclatide	Integrin	Inflammation/Immunology Cancer
Maraciclatide is a synthetic molecule that binds with high affinity to α_vβ₃ and α_vβ₅ integrins via the RGD peptide. Maraciclatide can be used to detect bone metastasis, breast tumors, vascular disease and rheumatoid arthritis in animal models. Maraciclatide can be studied in research on angiogenesis and inflammation .

HY-144452

Immunoproteasome inhibitor 1	Proteasome	Cancer
Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (K_is of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases .

HY-169134

PROTAC 20S proteasome subunit β5 degrader 1	PROTACs Apoptosis	Cancer
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) is a targeted degrader of PROTAC for 20S proteasome subunit β5, with a DC₅₀ value of 0.11 μM in FaDu cells. PROTAC 20S proteasome subunit β5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit β5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib (HY-10227) (Pink: Target protein ligand (HY-10227); Blue: E3 ligase ligand (HY-103596); Black: Linker (HY-169142)) .

HY-169144

Bortezomib analog	Proteasome	Cancer
Bortezomib analog (Compound 13), an analog of Bortezomib (HY-10227), is an active control of 20S proteasome subunit β5 ligand.

HY-10453R

Ixazomib (Standard) MLN2238 (Standard)	Reference Standards Proteasome Autophagy	Cancer
Ixazomib (Standard) is the analytical standard of Ixazomib. This product is intended for research and analytical applications. Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM).

HY-P10320

T3 Peptide Tumstatin (69-88), human	PI3K Akt	Cardiovascular Disease
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

HY-12040S

Elesclomol-d2 STA-4783-d₂	Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Apoptosis Cuproptosis	Cancer
Elesclomol-d₂ (STA-4783-d₂) is a deuterium labeled Elesclomol (HY-12040). Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-100206

5α-Androstane-3β,5,6β-triol	AMPK	Neurological Disease
5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo .

HY-150590

20S Proteasome-IN-2	Proteasome	Cancer
20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC₅₀ of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M .

HY-169158

Bortezomib analog 1	Ligands for Target Protein for PROTAC	Cancer
Bortezomib analog 1 is an analog of Bortezomib (HY-10227). Bortezomib analog 1 and can be used to synthesize PROTAC 20S proteasome subunit β5 degrader 1 (HY-169134) .

HY-150591

20S Proteasome-IN-3	Proteasome	Cancer
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM) . 20S Proteasome-IN-3 shows anti-tumor proliferation activity .

HY-P10677

HB-3-20	Integrin	Cancer
HB-3-20 leads to degradation of the cell surface integrin α_Vβ₅. Transglutaminase 2 (TG2) has specificity for HB-3-20 (k_cat/K_M=0.16 μM ^-1min ^-1) .

HY-P0295A

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

HY-W748328

Ixazomib-13C2,15N	Isotope-Labeled Compounds Autophagy Proteasome	Cancer
Ixazomib- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Ixazomib. Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

HY-170363

Proteasome-IN-6	Proteasome Parasite	Infection
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC₅₀s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model .

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-116030

JNJ-26076713	Integrin	Metabolic Disease
JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC₅₀ values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization .

HY-126402

Arg-Gly-Asp TFA	Integrin	Cancer
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.

HY-179394

Immunoproteasome-IN-2	Proteasome	Inflammation/Immunology
Immunoproteasome-IN-2 is selective immunoproteasome inhibitor with IC₅₀ = 232.3 nM for LMP7, IC₅₀ = 9384.9 nM for β5. Immunoproteasome-IN-2 exhibits ancillary inhibitory activity against LMP2 and MECL-1 subunits. Immunoproteasome-IN-2 demonstrates anti-inflammatory efficacy in a mouse model of arthritis and shows a favorable safety profile in toxicological studies with reduced hepatotoxicity and hematotoxicity. Immunoproteasome-IN-2 has *LMP7/β5* selectivity directly correlated with lower systemic toxicity. Immunoproteasome-IN-2 can be employed for research in arthritis .

HY-131171

3β,5α-Tetrahydronorethisterone 3β,5α-NET	Drug Derivative	Others
3β,5α-Tetrahydronorethisterone is a tetrahydro derivative of norethindrone (NET) .

HY-156297

β5i-IN-1	Proteasome	Inflammation/Immunology
β5i-IN-1 is a potent and selective inhibitor of *β5i* with a IC₅₀ of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis .

HY-169330

3β,5α,6β-Trihydroxycholanic acid	Drug Metabolite	Neurological Disease Metabolic Disease
3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction .

HY-N1202

Sitostanetriol Sitostane-3β,5α,6β-triol	Others	Others
Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) .

HY-146767S

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4	Isotope-Labeled Compounds	Others
(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d₄ is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.

Cat. No.	Nombre del producto

HY-L069

Anti-Alzheimer's Disease Compound Library

2,065 compounds

Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc.

MCE offers a unique collection of 2,065 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Cat. No.	Nombre del producto	Type

HY-D1705

Ac-ANW-AMC	Fluorescent Dyes
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure *β5i* activity (Ex=345 nm, Em=445 nm) .

HY-123051

Ac-WLA-AMC	Fluorescent Dyes
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-D2439

RGD-PEG-Cy3

Fluorescent Dyes

RGD-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, peptide (RGD) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. RGD is a peptide sequence (CRGDKGPDCiRGD) that binds to αvβ3 and αvβ5 integrin receptors on tumor neovasculogenesis to achieve specific tumor tissue targeting .

HY-P3110

Ac-DNLD-AMC	Fluorescent Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

Cat. No.	Nombre del producto	Type

HY-W010934

3β,5α,6β-Trihydroxycholestane

Biochemical Assay Reagents

3β,5α,6β-Trihydroxycholestane is a steroid that occurs naturally in the body and is also found in certain foods. It belongs to a class of compounds known as cholestanes, which are closely related to the better known cholesterol. This particular compound is formed from cholesterol through a series of enzymatic reactions in the liver and other organs. It has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. Some research suggests that it may also play a role in regulating blood sugar levels and improving insulin sensitivity. Despite these potential benefits, 3β,5α,6β-Trihydroxycholestane is not widely used as a supplement or medicine due to its relatively low content, focus on natural resources and limited research. However, researchers continue to investigate its potential uses and effects on human health.

Cat. No.	Nombre del producto	Target	Research Area

HY-P5133

Synstatin (92-119) 1 Publications Verification SSTN92-119	Integrin	Cancer
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupts the formation of the syndecan-1 : integrin : IGF1R ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-P0295

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ～5 and ～6.5 μM

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-P10030

DPLG3	Proteasome NF-κB	Inflammation/Immunology
DPLG3 is a specific chymotryptic-like *β5i* subunits inhibitor, with an IC₅₀ of 4.5 nM. DPLG3 inhibits mouse i-20S with IC₅₀ of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research .

HY-P2153

Maraciclatide	Integrin	Inflammation/Immunology Cancer
Maraciclatide is a synthetic molecule that binds with high affinity to α_vβ₃ and α_vβ₅ integrins via the RGD peptide. Maraciclatide can be used to detect bone metastasis, breast tumors, vascular disease and rheumatoid arthritis in animal models. Maraciclatide can be studied in research on angiogenesis and inflammation .

HY-P10320

T3 Peptide Tumstatin (69-88), human	PI3K Akt	Cardiovascular Disease
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

HY-P10677

HB-3-20	Integrin	Cancer
HB-3-20 leads to degradation of the cell surface integrin α_Vβ₅. Transglutaminase 2 (TG2) has specificity for HB-3-20 (k_cat/K_M=0.16 μM ^-1min ^-1) .

HY-P0295A

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-P3335

SU015 DOTA-RGDfK dimer	Integrin Radionuclide-Drug Conjugates (RDCs)	Cardiovascular Disease Cancer
SU015 (DOTA-RGDfK dimer) is a Integrin α_vβ₅ and α_vβ₃ antagonist. SU015 exhibits comparable affinity for α_vβ₅ and α_vβ₃, with relatively higher potency and specificity compared to other integrins. SU015 inhibits α_vβ₃-mediated cell adhesion to fibrinogen, α_vβ₃-mediated adhesion of activated platelets to osteopontin, and α_vβ₅-mediated cell adhesion to vitronectin. SU015 shows potent inhibitory effects on FGF2-induced angiogenesis in the CAM model. SU015 carries a linker arm available for radioisotope conjugation, and acts as a target-specific radioreagent when labeled with ⁹⁰Y (i.e., RP697) or ¹⁷⁷Lu (i.e., RP688). SU015 can be used in studies related to tumor metastasis and tumors .

HY-P11595

TBZ-1	Fluorescent Dye	Cancer
TBZ-1 is a fluorescent probe that monitors the activity of immunoproteasome (Proteasome) (iCP) in cells. TBZ-1 undergoes fluorescence activation after being selectively cleaved by β5i, which is used for intracellular activity monitoring. TBZ-1 is applicable to cancer-related research .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-10985

Marizomib 15+ Cited Publications Salinosporamide A; NPI-0052	Marine natural products Marine microorganism Source Classification	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-N1202

Sitostanetriol Sitostane-3β,5α,6β-triol	Triterpenes Clausena anisata (Willd.) Hook.f. ex Benth. Terpenoids Plants Salicaceae Source Classification	Others
Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) .

HY-12956B

(5R)-Dinoprost Prostaglandin F2β; PGF2β	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin .

HY-N13917

Argyrin B	Productos naturales Microorganisms Source Classification	Proteasome Bacterial
Argyrin B, a natural product cyclic peptide, is a reversible, non-competitive immunoproteasome inhibitor. Argyrin B shows selective inhibition of the β5i and β1i sites of the immunoproteasome over the β5c and β1c sites of the constitutive proteasome with nearly 20-fold selective inhibition of β1i over the homologous β1c. Argyrin B has antibacterial effects .

HY-N17043

3β,5α-Dihydroxystigmastan-6-one	Structural Classification Podocarpus nagi Podocarpaceae Plants Steroids Source Classification	Drug Derivative
3β,5α-Dihydroxystigmastan-6-one is a natural steroid.

HY-N15768

Tauro-3β,5α,6β-trihydroxycholanoic acid sodium	Lipid	Biochemical Assay Reagents
Tauro-3β,5α,6β-trihydroxycholanoic acid sodium is a bile acid (BA) suitable to investigate BAs and their relatives’ behavior and correlation with liver, gallbladder, and bile ducts diseases.

HY-N17477

3β,5α-Dihydroxy-6β-methoxyergosta-7,22-diene	Structural Classification Microorganisms Steroids Source Classification	Drug Derivative
3β,5α-Dihydroxy-6β-methoxyergosta-7,22-diene is a natural product that can be found in animal bile.

HY-N17400

(22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol	Structural Classification Tetracyclic Triterpenoids Microorganisms Terpenoids Steroids Source Classification	Others
(22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol (Compound 7) is an Ergosteroid. (22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol can be isolated from Penicillium herquei. (22E,24R)-23-Methylergosta-7,22-diene-3β,5α,6β-triol exhibits no obvious inhibitory activities against NO production induced by LPS .

HY-N10032

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol	Structural Classification Alkaloids Liliaceae Other Alkaloids Fritillaria ussuriensis Maxim. Plants Source Classification	Cholinesterase (ChE)
(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol (compound 3) is an inhibitor targeting acetylcholinesterase (AChE). At a concentration of 100 μg/mL, (3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol exhibits an in vitro inhibition rate of 12% against AChE .

HY-N17426

(3β,5α,6α,22E)-Ergosta-7,22-diene-3,5,6-triol	Structural Classification Productos naturales Microorganisms Hymenogastraceae Plants Source Classification Gymnopilus spectabilis	Drug Derivative
(3β,5α,6α,22E)-Ergosta-7,22-diene-3,5,6-triol is a natural product that can be found in animal bile.

HY-N17401

(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol	Structural Classification Tetracyclic Triterpenoids Microorganisms Terpenoids Steroids Source Classification	Drug Derivative
(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol is a natural product that can be found in Claviceps purpurea.

HY-N17427

(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol	Structural Classification Productos naturales Microorganisms Source Classification	Others
(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol (compound 3) is a sterol that can be found in of Grifola frondosa .

HY-N17478

(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol	Structural Classification Animals Steroids Source Classification	Drug Derivative
(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Compound 7) is a polyoxygenated sterol isolated from the sponge Homaxinella sp.

Species:	Human (3) Mouse (1) Cynomolgus (1)
Tag:	His (5) Tag Free (1) Avi (3)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P700766

	*Integrin alpha V beta 5* Protein, Human (Biotinylated, HEK293, His-Avi)** αVβ5; Integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5; Integrin alpha V β 5; β5	Human	HEK293
	Integrin α V beta 5 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 85-140 kDa.

HY-P77720

	*Integrin alpha V beta 5* Protein, Human (HEK293, His-Avi)** 1 Publications Verification Integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5	Human	HEK293
	Integrin α V beta 5 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi), has molecular weight of 85-160 kDa.

HY-P705052

	*Integrin alpha V beta 5* Protein, Mouse (Biotinylated, HEK293, His-Avi)** Integrin alpha V beta 5; ITGAV&ITGB5	Mouse	HEK293

HY-P704727

	*Integrin alpha V beta 5* Protein, Cynomolgus (HEK293, His)** Integrin alpha V beta 5,ITGAV&ITGB5	Cynomolgus	HEK293

HY-P7873

	Alpha-crystallin B chain/CRYAB Protein, Human (His) 1 Publications Verification rHuAlpha-crystallin B chain/CRYAB, His; Alpha-Crystallin B Chain; Alpha(B)-Crystallin; Heat Shock Protein Beta-5; HspB5; Renal Carcinoma Antigen NY-REN-27; Rosenthal Fiber Component; CRYAB; CRYA2	Human	E. coli
	Alpha-crystallin B chain/CRYAB Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. CRYAB is an important member of the small heat shock protein family, and plays a protective role in neurological inflammation.

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Cat. No.	Nombre del producto	Chemical Structure

HY-12040S

Elesclomol-d2

Elesclomol-d₂ (STA-4783-d₂) is a deuterium labeled Elesclomol (HY-12040). Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-W748328

Ixazomib-13C2,15N
Ixazomib- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Ixazomib. Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

HY-146767S

(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4
(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d₄ is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.

HY-10453S

Ixazomib-d7
Ixazomib-d₇ is the deuterium labeled Ixazomib (HY-10453). Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

HY-W010934S

3β,5α,6β-Trihydroxycholestane-d7
3β,5α,6β-Trihydroxycholestane-d₇ is the deuterium labeled 3β,5α,6β-Trihydroxycholestane .

Host:	Mouse (9) Rabbit (7)
Reactivity:	Human (14) Mouse (8) Rat (12) Hamster (2) Pig (1)
Application:	IHC-P (10) ICC/IF (11) IF-Tissue (3) IHC-F (8) WB (11) FC (4) ELISA (5)
Isotype:	IgG (7) IgG1 (4) IgG2a (2)
Conjugation:	Non-conjugated (16) Biotin (2)
Clonality:	Polyclonal (2) Monoclonal (8) Monoclonal Antibody (1) Recombinant (3)
Modification:	Phosphorylated (1) Unmodified (10)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P83363

	*Integrin beta 5* Antibody (YA3108)** Integrin beta-5	WB	Human, Hamster, Rat
	Integrin beta 5 Antibody (YA3108) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 5.

HY-P83363A

	*Integrin beta 5* Antibody (YA3108)(PBS only)** Integrin beta-5	WB	Human, Hamster, Rat
	Integrin beta 5 Antibody (YA3108) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 5.

HY-P84144

	*Integrin beta 5* Antibody (YA3841)**	ICC/IF, FC, ELISA	Human
	Integrin beta 5 Antibody (YA3841) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin beta 5.

HY-P84144A

	*Integrin beta 5* Antibody (YA3841)(PBS only)**	ICC/IF, FC, ELISA	Human
	Integrin beta 5 Antibody (YA3841) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin beta 5.

HY-P82522

	beta IV Tubulin Antibody (YA2267) DYT4; TUBB4; beta-5	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	beta IV Tubulin Antibody (YA2267) is a rabbit-derived non-conjugated IgG monoclonal antibody (Clone NO.: YA2267), targeting beta IV Tubulin. It can be used as a loading control antibody.

HY-P85805

	Beta Tubulin Antibody (YA5497) Tubulin beta chain (Tubulin beta-5 chain)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Pig
	Beta Tubulin Antibody (YA5497) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Beta Tubulin.

HY-P82522A

	beta IV Tubulin Antibody (YA2267)(PBS only) DYT4; TUBB4; beta-5	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	beta IV Tubulin Antibody (YA2267) is a rabbit-derived non-conjugated IgG monoclonal antibody (Clone NO.: YA2267), targeting beta IV Tubulin. It can be used as a loading control antibody.

HY-P85110

	Alpha B Crystallin Antibody (YA4802) CRYAB; CRYA2; Alpha-crystallin B chain; Alpha; B; -crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component	WB, IHC-P, ICC/IF, ELISA	Human
	Alpha B Crystallin Antibody (YA4802) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Alpha B Crystallin.

HY-P83719

	PSMB5/MB1 Antibody DKFZp459C139 antibody; EC 3.4.25.1 antibody; LMPX antibody; Macropain epsilon chain antibody; MB1 antibody; MGC104214 antibody; MGC118075 antibody; MGC134464 antibody; Multicatalytic endopeptidase complex epsilon chain antibody; Proteasome (prosome, macropain) subunit, beta type, 5 antibody; Proteasome beta 5 subunit antibody; Proteasome catalytic subunit 3 antibody; Proteasome chain 6 antibody; Proteasome epsilon chain antibody; Proteasome subunit beta type-5 antibody; Proteasome subunit MB1 antibody; Proteasome subunit X antibody; Proteasome subunit, beta type, 5 antibody; Proteasome subunit, beta-5 antibody; PSB5_HUMAN antibody; PSMB5 antibody; PSX large multifunctional protease X antibody; X antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PSMB5/MB1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PSMB5/MB1.

HY-P80876

	Proteasome 20S LMP7 Antibody (YA684) PSMB8; LMP7; PSMB5i; RING10; Y2; Proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome 20S LMP7 Antibody (YA684) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P85261

	Proteasome 20S LMP7 Antibody (YA4953) PSMB8; LMP7; PSMB5i; RING10; Y2; Proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	Proteasome 20S LMP7 Antibody (YA4953) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P80876A

	Proteasome 20S LMP7 Antibody (YA684)(PBS only) PSMB8; LMP7; PSMB5i; RING10; Y2; Proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome 20S LMP7 Antibody (YA684) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P86743

	TGF beta 1 Antibody (YA6435) CED; DPD1; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta 1 protein; TGF-beta-1; TGF-beta-5; TGF-beta1; TGFB; Tgfb-1; tgfb1; TGFB1_HUMAN; TGFbeta; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; transforming growth factor beta-1; transforming growth factor, beta 1.	IHC-P, IHC-F, IF-Tissue	Rat, Mouse
	TGF beta 1 Antibody (YA6435) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGF beta 1.

HY-P86743A

	TGF beta 1 Antibody (YA6435)(PBS only) CED; DPD1; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta 1 protein; TGF-beta-1; TGF-beta-5; TGF-beta1; TGFB; Tgfb-1; tgfb1; TGFB1_HUMAN; TGFbeta; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; transforming growth factor beta-1; transforming growth factor, beta 1.	IHC-P, IHC-F, IF-Tissue	Rat, Mouse
	TGF beta 1 Antibody (YA6435) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGF beta 1.

HY-P85015

	HLA-DR Antibody (YA4707) DASS-397D15.1 antibody; DR alpha chain antibody; DR alpha chain precursor antibody; DRA_HUMAN antibody; DRB1 antibody; DRB4 antibody; FLJ51114 antibody; Histocompatibility antigen HLA DR alpha antibody; Histocompatibility antigen HLA-DR alpha antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR alpha chain antibody; HLA DR1B antibody; HLA DR3B antibody; HLA DRA antibody; HLA DRA1 antibody; HLA DRB1 antibody; HLA DRB3 antibody; HLA DRB4 antibody; HLA DRB5 antibody; HLA-DR histocompatibility type antibody; HLA-DRA antibody; HLADR4B antibody; HLADRA1 antibody; HLADRB antibody; Major histocompatibility complex class II DR alpha antibody; Major histocompatibility complex class II DR beta 1 antibody; Major histocompatibility complex class II DR beta 3 antibody; Major histocompatibility complex class II DR beta 4 antibody; Major histocompatibility complex class II DR beta 5 antibody; MGC117330 antibody; MHC cell surface glycoprotein antibody; MHC class II antigen DRA antibody; MHC II antibody; MLRW antibody; OTTHUMP00000029406 antibody; OTTHUMP00000029407 antibody; HLA-DRA nanobody;	ELISA	Human
	HLA-DR Antibody (YA4707) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HLA-DR.

HY-P81211

	phospho-PI3 Kinase p110 beta (Ser1070) Antibody 5+ Cited Publications PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	phospho-PI3 Kinase p110 beta (Ser1070) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-PI3 Kinase p110 beta (Ser1070).

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