αvβ5 integrin-IN-1

Cat. No.: HY-145363 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC₅₀ = 8.2) .

For research use only. We do not sell to patients.

αvβ5 integrin-IN-1 Chemical Structure

CAS No. : 2615912-33-7

Size	Price	Stock	Quantity
5 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4950	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 7900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC₅₀ = 8.2) .

IC₅₀ & Target

αvβ5

8.2 (pIC₅₀)

Molecular Weight

475.50

Formula

C₂₅H₂₈F₃N₃O₃

CAS No.

2615912-33-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@@H](CC1)CCC(N2)=CC=C3C2=NCCC3)[C@H](C4=CC(C(F)(F)F)=CC=C4)CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (210.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1030 mL	10.5152 mL	21.0305 mL
5 mM	0.4206 mL	2.1030 mL	4.2061 mL
10 mM	0.2103 mL	1.0515 mL	2.1030 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) HNMR (145 KB) RP-HPLC (171 KB) LCMS (232 KB)

Handling Instructions (2659 KB)

References

[1]. Lippa RA, et al. Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. Eur J Med Chem. 2020 Dec 15;208:112719. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1030 mL	10.5152 mL	21.0305 mL	52.5762 mL
	5 mM	0.4206 mL	2.1030 mL	4.2061 mL	10.5152 mL
	10 mM	0.2103 mL	1.0515 mL	2.1030 mL	5.2576 mL
	15 mM	0.1402 mL	0.7010 mL	1.4020 mL	3.5051 mL
	20 mM	0.1052 mL	0.5258 mL	1.0515 mL	2.6288 mL
	25 mM	0.0841 mL	0.4206 mL	0.8412 mL	2.1030 mL
	30 mM	0.0701 mL	0.3505 mL	0.7010 mL	1.7525 mL
	40 mM	0.0526 mL	0.2629 mL	0.5258 mL	1.3144 mL
	50 mM	0.0421 mL	0.2103 mL	0.4206 mL	1.0515 mL
	60 mM	0.0351 mL	0.1753 mL	0.3505 mL	0.8763 mL
	80 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6572 mL
	100 mM	0.0210 mL	0.1052 mL	0.2103 mL	0.5258 mL