935888-69-0
Chemical Structure
Oprozomib
Synonym(s): ONX 0912; PR-047
- CAS 番号: 935888-69-0
- Formula:C25H32N4O7S
- Molecular Weight:532.61
IUPAC Name: N-((S)-3-methoxy-1-(((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide
InChIKey: SWZXEVABPLUDIO-WSZYKNRRSA-N
SMILES: C[C@]1(OC1)C([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(C3=CN=C(C)S3)=O)COC)=O)COC)=O)=O
Biological Activity: Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Oprozomib | 99.76% | Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells. | ||||||||||||||||||||
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Similarity Score 0.84
HY-117520FV-162 -
Similarity Score 0.60
HY-101786KZR-504 -
Similarity Score 0.59
HY-13207ONX-0914 -
Similarity Score 0.56
HY-182325DB-310 -
Similarity Score 0.56
HY-150226Enzyme-IN-1 -
Similarity Score 0.52
HY-10455RCarfilzomib (Standard) -
Similarity Score 0.52
HY-170363Proteasome-IN-6 -
Similarity Score 0.52
HY-129230Triletide -
Similarity Score 0.52
HY-I0775(S)-methyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate -
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