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1123-95-1

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1 Results for "1123-95-1" in MCE Product Catalog:

5-Hydroxymethylcytosine
5-Hydroxymethylcytosine
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Cat. No.: HY-W018324
CAS No.: 1123-95-1
Synonyms: 5hmC
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite

5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .
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