1 Result for "

2411851-64-2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2411851-64-2" in MCE Product Catalog:

Cat. No.: HY-P10436
CAS No.: 2411851-64-2
Target:  

Raf

Research Areas:  

Cancer

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research .
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