2 Results for "

83-95-4

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "83-95-4" in MCE Product Catalog:

4
Skimmianine
Skimmianine
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4 Cited Publications
Cat. No.: HY-N2081
CAS No.: 83-95-4
Category:  

Alkaloids Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE) PI3K Akt NF-κB

Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
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Skimmianine (Standard)
Skimmianine (Standard)
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Cat. No.: HY-N2081R
CAS No.: 83-95-4
Category:  

Alkaloids Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort.

Target:  

Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB

Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
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