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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
ALR2/AKR1B1
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "ALR2/AKR1B1" in MCE Product Catalog:
1
Target:
Research Areas:
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
Cat. No.: HY-175331
CAS No.: 59935-47-6
Target:
Research Areas:
ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .
Cat. No.: HY-175639
Target:
Research Areas:
ALR2-IN-8 is a potent aldose reductase (ALR2/AKR1B1) inhibitor with a KI of 7.34 nM. ALR2-IN-8 has extremely low toxicity to normal cells and has a weak direct killing effect on cancer cells. ALR2-IN-8 can used for the studies of diabetic and inflammation-linked disorders .
Cat. No.: HY-106697R
CAS No.: 72702-95-5
Synonyms: ICI 128436 (Standard)
Target:
Research Areas:
Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
Cat. No.: HY-P75521
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1B1; ALR2; Prev. ALDR1; Lii5-2 CTCL Tumor Antigen; Aldose Reductase; Low Km Aldose Reductase; AR; Aldehyde Reductase 1; Aldo-Keto Reductase Family 1 Member B1; ADR; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member B; Aldo-Keto Reductase Family 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P85558
Synonyms: ADR; AKR1B 1; AKR1B1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1; aldose reductase; Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
