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Results for "

Antituberculosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (16) Apoptosis (2) ATP Synthase (1) ATP-binding cassette (ABC) transporters (1) Autophagy (1) Bacterial (113) Biochemical Assay Reagents (3) Carbonic Anhydrase (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (3) Drug Derivative (1) Drug Intermediate (12) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (5) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (1) Fungal (7) HSP (1) Interleukin Related (3) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) MDM-2/p53 (1) MOFs (1) NF-κB (1) NO Synthase (1) p38 MAPK (2) Parasite (2) Phosphatase (1) Potassium Channel (1) Reactive Oxygen Species (ROS) (3) Reference Standards (14) SARS-CoV (1) Ser/Thr Protease (3) STAT (4) Thrombopoietin Receptor (3) TNF Receptor (1) Topoisomerase (2) VEGFR (1) Virus Protease (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Endocrinology (1) Infection (121) Inflammation/Immunology (21) Metabolic Disease (6) Neurological Disease (4)

By Targets:

AMPK (1)

Antibiotic (16)

Apoptosis (2)

ATP Synthase (1)

ATP-binding cassette (ABC) transporters (1)

Autophagy (1)

Bacterial (113)

Biochemical Assay Reagents (3)

Carbonic Anhydrase (1)

Cytochrome P450 (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (3)

Drug Derivative (1)

Drug Intermediate (12)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (5)

Environmental Pollutants (1)

Epigenetic Reader Domain (1)

ERK (1)

Fungal (7)

HSP (1)

Interleukin Related (3)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (1)

MDM-2/p53 (1)

MOFs (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (2)

Parasite (2)

Phosphatase (1)

Potassium Channel (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (14)

SARS-CoV (1)

Ser/Thr Protease (3)

STAT (4)

Thrombopoietin Receptor (3)

TNF Receptor (1)

Topoisomerase (2)

VEGFR (1)

Virus Protease (1)

Xanthine Oxidase (2)

By Research Areas:

Cancer (14)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (121)

Inflammation/Immunology (21)

Metabolic Disease (6)

Neurological Disease (4)

136

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0276

Ethionamide 5 Publications Verification 2-Ethylthioisonicotinamide	Bacterial Antibiotic	Infection
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity .

HY-12903

Macozinone 5 Publications Verification PBTZ169	Bacterial Antibiotic	Infection
Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect .

HY-W010589

L-2-Aminobutyric acid H-Abu-OH	Endogenous Metabolite Drug Intermediate	Metabolic Disease
L-2-Aminobutyric acid (H-Abu-OH) is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-76260

Faropenem sodium 2 Publications Verification	Bacterial Antibiotic	Infection
Faropenem sodium is an orally bioavailable penem antibiotic. Faropenem sodium regulates inorganic phosphate transporter Npt1. Faropenem sodium inhibits M. tuberculosis (MIC of 1.3 μg/mL) and B. anthracis .

HY-177105

JNJ-6640	Bacterial	Infection
JNJ-6640 is an inhibitor targeting mycobacterial PurF (the first enzyme in the de novo purine biosynthesis pathway) with potent anti-tuberculosis activity. JNJ-6640 exhibits bactericidal activity against Mycobacterium tuberculosis in vitro, with an MIC₉₀ of 8.6 nM. JNJ-6640 disrupts de novo purine biosynthesis, inhibits M. tuberculosis DNA replication in vivo. JNJ-6640 exhibits anti-tuberculosis efficacy in acutely infected mice. JNJ-6640 can be used for the study of tuberculosis .

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs .

HY-134940

Quabodepistat 3 Publications Verification OPC-167832	Bacterial	Infection Inflammation/Immunology
Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with an IC₅₀ of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase	Cardiovascular Disease Cancer
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-W010611

3,3-Dimethylacrylic acid 3-Methylcrotonic acid; 3-Methylbut-2-enoic acid	Environmental Pollutants Bacterial	Infection
3,3-Dimethylacrylic acid is an active small molecule, that can be used as drug intermediate .

HY-W005327

1-Hydroxy-2-butanone	Bacterial Drug Intermediate	Infection Inflammation/Immunology
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice. 1-Hydroxy-2-butanone acts as a key intermediate for ethambutol. Ethambutol has anti-tuberculosis effects .

HY-148564

TBI-166	Bacterial	Infection
TBI-166, a riminophenazine analogue, is an orally active anti-tuberculosis agent with fewer adverse reactions than the lead riminophenazine compound, Clofazimine (HY-B1046) .

HY-100531

DprE1-IN-2	Bacterial	Infection
DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC₅₀ of 28 nM. DprE1-IN-2 has antituberculosis effect .

HY-148478

MMV688845 (R)-GSK1729177A	DNA/RNA Synthesis	Infection
MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .

HY-W028047

JFD01307SC	Bacterial	Infection Inflammation/Immunology
JFD01307SC is a glutamine synthetase inhibitor and anti-tuberculosis agent. JFD01307SC acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis .

HY-117145

Thiophene-2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .

HY-W013677

4-Fluorobenzoic acid	Drug Intermediate	Infection
4-Fluorobenzoic acid is a drug intermediate that can be used to synthesize a series of hydrazone derivatives with antituberculosis activity and Schiff bases with DPPH radical scavenging activity .

HY-14990

Sudoterb LL 3858	Bacterial	Infection
Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent .

HY-W128705

3-Phenylindole 3-Phenyl-1H-indole	Bacterial	Infection
3-Phenylindole (3-phenyl-1H-indole) is an indole compound. 3-Phenylindole exhibits weak anti-tuberculosis activity with an MIC of 129.4 μM. 3-Phenylindole can be utilized in anti-tuberculosis research .

HY-112091

GSK2200150A	Bacterial	Infection
GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent.

HY-76210

5-Hydroxypyrazine-2-Carboxylic Acid 1 Publications Verification	Bacterial Antibiotic	Others
5-Hydroxypyrazine-2-Carboxylic Acid, a metabolite of anti-tuberculosis drug pyrazinamide (PZA).

HY-12485

TBA-354	Bacterial Antibiotic	Infection
TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains.

HY-128866A

(Rac)-TBAJ-876	Bacterial	Infection
(Rac)-TBAJ-876 is a racemate of TBAJ-876. TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline (HY-14881). TBAJ-876 has the potential for the research of tuberculosis .

HY-178436

Antituberculosis agent-16	Bacterial	Infection
Antituberculosis agent-16 is an orally active antituberculosis agent. Antituberculosis agent-16 exhibits stable antituberculosis activity with a MIC of 0.48 μg/mL against Mycobacterium tuberculosis H37Rv sensitive strain and 0.49 μg/mL against multidrug-resistant strain 14862. Antituberculosis agent-16 shows high Caco-2 permeability. Antituberculosis agent-16 can be used for the research of infection .

HY-B1040

Ftaxilide 1 Publications Verification	Bacterial	Infection
Ftaxilide is a novel antituberculosis agent.

HY-W716673

Ftivazide Phthivazide	Bacterial	Infection
Ftivazide has anti-tuberculosis activity .

HY-B0276R

Ethionamide (Standard) 2-Ethylthioisonicotinamide (Standard)	Reference Standards Bacterial Antibiotic	Infection
Ethionamide (Standard) is the analytical standard of Ethionamide. This product is intended for research and analytical applications. Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.

HY-126597

Chaetoglobosin C	Bacterial	Infection
Chaetoglobosin C (Compound 4) is a anthraquinone-chromone compound derived from the fungus Chaetomium globosum KMITL-N0802. Chaetoglobosin C has anti-tuberculosis activity .

HY-151514

Antituberculosis agent-5	Bacterial	Infection
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC₅₀ value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .

HY-152138

Antituberculosis agent-8	Bacterial Fungal	Infection
Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against **M. tuberculosis* H37Rv**. Antituberculosis* agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM .

HY-W129661

Pyrazine-2-carbothioamide	Bacterial	Infection
Pyrazine-2-carbothioamide is an effective antituberculosis agent with inhibitory activity against mycobacterium in vitro .

HY-146055

Antituberculosis agent-1	Bacterial	Infection
Antituberculosis agent-1 (Compound 8a) is an antituberculosis agent with an MIC of 3.84 μg/mL against M. tuberculosis H₃₇R_v .

HY-142031

4-Piperidinecarboxamide	Bacterial	Infection
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .

HY-W738288

Rifamdin	Bacterial Drug Derivative DNA/RNA Synthesis	Infection
Rifamdin is a derivative of Rifampicin (HY-B0272). Rifamdin is an anti-tuberculosis agent. Rifamdin exerts its antibacterial effect by inhibiting the synthesis of bacterial RNA .

HY-32806

2-Chloro-4-methyl-3-nitropyridine	Drug Intermediate	Infection
2-Chloro-4-methyl-3-nitropyridine is a pyridine derivative that can be used to synthesize 2-methoxypyridine derivatives with antibacterial and antituberculosis activities .

HY-151956

Mtb-cyt-bd oxidase-IN-7	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-7 is a cytochrome bd terminal oxidase (Cyt-bd) inhibitor with a K_d value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities .

HY-N11259

Sophoradiol	Bacterial	Infection
Sophoradiol is a triterpenoid compound that can be extracted from Abrus Precatorius. Sophoradiol is an orally effective anti-tuberculosis agent. Sophoradiol has inhibitory activity against various strains of Mycobacterium tuberculosis. Sophoradiol has good biocompatibility. Sophoradiol can be used in the research of tuberculosis .

HY-Y0030R

3-Hydroxypicolinic acid (Standard)	Reference Standards Biochemical Assay Reagents Drug Intermediate	Infection
3-Hydroxypicolinic acid is a matrix. 3-Hydroxypicolinic acid coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid is useful for nucleic acid analysis and anti-tuberculosis compound development .

HY-146057

Antituberculosis agent-2	Bacterial	Infection
Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H₃₇R_v, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability .

HY-151205

Antituberculosis agent-3	Bacterial	Infection Inflammation/Immunology
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .

HY-152136

Antituberculosis agent-6	Bacterial Fungal	Infection
Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption .

HY-163486

Antituberculosis agent-10	Bacterial	Infection
Antituberculosis agent-10 (Compound 9) has excellent antibacterial activity against Mycobacterium tuberculosis (MIC = 0.3 μM). Antituberculosis agent-10 inhibits protein synthesis by targeting the 50S ribosomal subunit of the bacterium, thus exerting its antibacterial effect. Antituberculosis agent-10 is orally active .

HY-152137

Antituberculosis agent-7	Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Antituberculosis agent-7, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis with a MIC of 31.25 μM. Antituberculosis agent-7 shows good antifungal activity against A. niger with a MIC of 62.5 μM. Antituberculosis agent-7 shows excellent antimycobacterial activity with MIC 3.41 μM for M. tuberculosis H37Rv .

HY-168860

Antituberculosis agent-13	Bacterial	Infection Cancer
Antituberculosis agent-13 (Compound 11) inhibits Mycobacterium tuberculosis, that inhibits Mtb wildtype and mutated strains with IC₅₀ of 4-62.5 nM. Antituberculosis agent-13 exhibits anti-leukemia activity that inhibits MOLM-13 with IC₅₀ of 3.8 μM .

HY-175183

Antituberculosis agent-15	Bacterial	Infection
Antituberculosis agent-15 (Compound 18c) is a selective antimycobacterial agent with MICs of 0.45 and 0.28  μM for M. tuberculosis H37Rv (ATCC 27294) and its wild-type H37Rv-LP (ATCC 25618), respectively. Antituberculosis agent-15 has potent intracellular inhibitory activities in macrophage infection models with IC₅₀s of 0.16  μM. Antituberculosis agent-15 can be used for tuberculosis research .

HY-149064

Antituberculosis agent-9	Bacterial	Infection
Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra .

HY-169108

DprE1-IN-11	Bacterial	Infection
DprE1-IN-11 (compound 3) is an orally active DprE1 inhibitor with antituberculosis activity against MTB H37Rv and MDR-MTB strains (MIC <0.029-0.095 μM) .

HY-156412

DHFR-IN-10	Bacterial	Infection
DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC₅₀ of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency .

HY-168946

InhA-IN-9	Bacterial	Infection
InhA-IN-9 (compound 7h) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor. InhA-IN-9 could bind to InhA. InhA-IN-9 shows a antituberculosis activity at MIC value of 2 μg/mL .

HY-12903R

Macozinone (Standard) PBTZ169 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Macozinone (Standard) is the analytical standard of Macozinone. This product is intended for research and analytical applications. Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].

HY-N13197

6-Methyl-5,6-dihydro-2H-pyran-2-one	Antibiotic Bacterial Fungal Parasite	Infection Inflammation/Immunology Cancer
6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities .

Cat. No.	Product Name

HY-L142

Anti-tuberculosis Compound Library

151 compounds

Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases.

Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs.

MCE supplies a unique collection of 151 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Cat. No.	Product Name	Type

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Biochemical Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-Y0030A

3-Hydroxypicolinic acid, matrix substance for MALDI-MS

3-HPA

Biochemical Assay Reagents

3-Hydroxypicolinic acid, matrix substance for MALDI-MS is a matrix. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is useful for nucleic acid analysis and anti-tuberculosis compound development .

HY-W013677

4-Fluorobenzoic acid	Biochemical Assay Reagents
4-Fluorobenzoic acid is a drug intermediate that can be used to synthesize a series of hydrazone derivatives with antituberculosis activity and Schiff bases with DPPH radical scavenging activity .

HY-32806

2-Chloro-4-methyl-3-nitropyridine	Biochemical Assay Reagents
2-Chloro-4-methyl-3-nitropyridine is a pyridine derivative that can be used to synthesize 2-methoxypyridine derivatives with antibacterial and antituberculosis activities .

HY-D0837R

Imidazole (Standard)

Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)

Biochemical Assay Reagents

Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

Cat. No.	Product Name	Target	Research Area

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-14743R

Golotimod (Standard) SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)	Bacterial STAT Reference Standards	Infection Inflammation/Immunology Cancer
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0276

Ethionamide 5 Publications Verification 2-Ethylthioisonicotinamide	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity .

HY-W010589

L-2-Aminobutyric acid H-Abu-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
L-2-Aminobutyric acid (H-Abu-OH) is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-N1887

4-Allylcatechol 1 Publications Verification Hydroxychavicol; 4-Allylpyrocatechol	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Antibiotic TNF Receptor Interleukin Related
4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC₅₀ = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL) .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Cancer	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-W010611

3,3-Dimethylacrylic acid 3-Methylcrotonic acid; 3-Methylbut-2-enoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Bacterial
3,3-Dimethylacrylic acid is an active small molecule, that can be used as drug intermediate .

HY-W005327

1-Hydroxy-2-butanone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Drug Intermediate
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice. 1-Hydroxy-2-butanone acts as a key intermediate for ethambutol. Ethambutol has anti-tuberculosis effects .

HY-N2208

4-Hydroxylonchocarpin 2 Publications Verification	Classification of Application Fields Metabolic Disease Plants Infection Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

HY-N11722

Panduratin A	Structural Classification Phenols Polyphenols Boesenbergia rotunda Plants Source Classification Zingiberaceae	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-B0276R

Ethionamide (Standard) 2-Ethylthioisonicotinamide (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Ethionamide (Standard) is the analytical standard of Ethionamide. This product is intended for research and analytical applications. Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.

HY-126597

Chaetoglobosin C	Alkaloids Microorganisms Indole Alkaloids Source Classification	Bacterial
Chaetoglobosin C (Compound 4) is a anthraquinone-chromone compound derived from the fungus Chaetomium globosum KMITL-N0802. Chaetoglobosin C has anti-tuberculosis activity .

HY-N11259

Sophoradiol	Triterpenes Structural Classification Leguminosae Terpenoids Abrus precatorius Linn. Plants Source Classification	Bacterial
Sophoradiol is a triterpenoid compound that can be extracted from Abrus Precatorius. Sophoradiol is an orally effective anti-tuberculosis agent. Sophoradiol has inhibitory activity against various strains of Mycobacterium tuberculosis. Sophoradiol has good biocompatibility. Sophoradiol can be used in the research of tuberculosis .

HY-Y0030R

3-Hydroxypicolinic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Biochemical Assay Reagents Drug Intermediate
3-Hydroxypicolinic acid is a matrix. 3-Hydroxypicolinic acid coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid is useful for nucleic acid analysis and anti-tuberculosis compound development .

HY-N13197

6-Methyl-5,6-dihydro-2H-pyran-2-one	Natural Products Microorganisms Source Classification	Antibiotic Bacterial Fungal Parasite
6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities .

HY-W010611R

3,3-Dimethylacrylic acid (Standard) 3-Methylcrotonic acid (Standard); 3-Methylbut-2-enoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial
3,3-Dimethylacrylic acid (Standard) (3-Methylcrotonic acid (Standard)) is the analytical standard of 3,3-Dimethylacrylic acid (HY-W010611). This product is intended for research and analytical applications.3,3-Dimethylacrylic acid is an active small molecule, that can be used as drug intermediate.

HY-113095R

γ-CEHC (Standard)	Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
Ftivazide (Standard) is the analytical standard of Ftivazide. This product is intended for research and analytical applications. Ftivazide has anti-tuberculosis activity .

HY-N8388

Collinin	Zanthoxylum schinifolium Sieb. et Zucc. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial
Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains .

HY-122448A

(Rac)-Sativan	Flavonoids Leguminosae Trifolium pratense Linn. Plants Source Classification	Bacterial Fungal
(Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL .

HY-N0872R

Isosteviol (Standard) (-)-Isosteviol (Standard); iso-Steviol (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Interleukin Related Reference Standards Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-114604

Propioxatin B	Natural Products Microorganisms Source Classification	Bacterial
Propioxatin B is a tricyclic sesquiterpenoid compound isolated from the root of vetiver grass. It has anti-tuberculosis activity and inhibitory effects on a variety of drug-resistant mutants of Mycobacterium tuberculosis. In computer simulation docking studies, it showed binding affinity with bacterial DNA gyrase and has a certain safety in vivo.

HY-N12232

Carbazomycin D	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Parasite Bacterial
Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC₅₀ > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC₅₀s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .

HY-W005327R

1-Hydroxy-2-butanone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Drug Intermediate
1-Hydroxy-2-butanone (Standard) is the analytical standard of 1-Hydroxy-2-butanone. This product is intended for research and analytical applications. 1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice. 1-Hydroxy-2-butanone acts as a key intermediate for ethambutol. Ethambutol has anti-tuberculosis effects[1][2].

HY-W010589R

L-2-Aminobutyric acid (Standard) H-Abu-OH (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Intermediate
L-2-Aminobutyric acid (Standard) is the analytical standard of L-2-Aminobutyric acid. This product is intended for research and analytical applications. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-N11733

D-Glucoheptose	Structural Classification Vitis vinifera cv. Zalema Plants Vitaceae Saccharides Monosaccharides Source Classification	Bacterial
D-Glucoheptose is a heptose monosaccharide that serves as a starting material for sedoheptulose. D-Glucoheptose has a strong association with the genus Symbiobacterium. The content of D-Glucoheptose in urine of the control group without liver injury is higher than that in the anti-tuberculosis drug-induced liver injury group. D-Glucoheptose can be used in studies related to anti-tuberculosis drug-induced liver injury .

HY-N9229

Myricadenin A	Structural Classification Natural Products Other Phenylpropanoids Phenylpropanoids Plants Morella adenophora (Hance) J. Herb. Source Classification Myricaceae	NO Synthase Bacterial
Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research .

Cat. No.	Product Name	Chemical Structure

HY-W018677S

Quinoxaline-d4
Quinoxaline-d₄ is the deuterium labeled Quinoxaline . Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics .

HY-W013677S

4-Fluorobenzoic acid-13C6
4-Fluorobenzoic acid- ¹³C₆ is the ¹³C₆ labeled 4-Fluorobenzoic acid (HY-W013677). 4-Fluorobenzoic acid is a drug intermediate that can be used to synthesize a series of hydrazone derivatives with antituberculosis activity and Schiff bases with DPPH radical scavenging activity.

HY-134940S

Quabodepistat-d7
Quabodepistat-d₇ (OPC-167832-d₇) is deuterium labeled Quabodepistat. Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with?an IC₅₀ of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis?caused by?Mycobacterium tuberculosis .

HY-W010589S2

L-2-Aminobutyric acid-d6

L-2-Aminobutyric acid-d₆ is the deuterium labeled L-2-Aminobutyric acid. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-W010589S

L-2-Aminobutyric acid-d3

L-2-Aminobutyric acid-d₃ is the deuterium labeled L-2-Aminobutyric acid. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-W013677S1

4-Fluorobenzoic acid-13C,d4
4-Fluorobenzoic acid- ¹³C,d₄ is the ¹³C- and deuterium labeled 4-Fluorobenzoic acid (HY-W013677). 4-Fluorobenzoic acid is a drug intermediate that can be used to synthesize a series of hydrazone derivatives with antituberculosis activity and Schiff bases with DPPH radical scavenging activity .

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