2. Anti-infection
  3. Bacterial
  4. TBI-166

TBI-166, a riminophenazine analogue, is an orally active anti-tuberculosis agent with fewer adverse reactions than the lead riminophenazine compound, Clofazimine (HY-B1046) .

For research use only. We do not sell to patients.

TBI-166 Chemical Structure

TBI-166 Chemical Structure

CAS No. : 1353734-12-9

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

TBI-166 Related Antibodies

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Description

TBI-166, a riminophenazine analogue, is an orally active anti-tuberculosis agent with fewer adverse reactions than the lead riminophenazine compound, Clofazimine (HY-B1046) [1][2][3].

In Vitro

TBI-166 inhibits M. tuberculosis H37Rv replicates (MIC: 0.063 μg/mL), and is effective against 16 drug-sensitive clinical isolates (Mycobacterial species) with MICs of 0.005-0.15 μg/mL[1].
TBI-166 (0-1 μg/mL, 3 days) inhibits intracellular M. tuberculosis in M. tuberculosis infecting J774A.1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TBI-166 Related Antibodies
In Vivo

TBI-166 (10-80 mg/kg, p.o., 8 weeks) displays antituberculosis activity in chronic murine M. tuberculosis H37Rv infected model[1].
TBI-166 displays a LD50 more than 3,000 mg/kg in mice[1].
TBI-166 has a short half-life (41.25 h) and reduces the potential for skin pigmentation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic murine M. tuberculosis H37Rv infected model[1]
Dosage: 10, 20, 80 mg/kg
Administration: Oral administration, 8 weeks.
Result: Reduced CFU counts in lung.
Clinical Trial
Molecular Weight

589.61

Formula

C32H30F3N5O3
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

FC(F)(F)OC1=CC=C(N2C3=C/C(C(NC4=CC=CN=C4OC)=CC3=NC5=C2C=CC=C5)=N/C6CCC(OC)CC6)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.09 mg/mL (15.42 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6960 mL 8.4802 mL 16.9604 mL
5 mM 0.3392 mL 1.6960 mL 3.3921 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6960 mL 8.4802 mL 16.9604 mL 42.4009 mL
5 mM 0.3392 mL 1.6960 mL 3.3921 mL 8.4802 mL
10 mM 0.1696 mL 0.8480 mL 1.6960 mL 4.2401 mL
15 mM 0.1131 mL 0.5653 mL 1.1307 mL 2.8267 mL
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TBI-166 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBI-1661353734-12-9TBI166TBI 166BacterialTuberculosisTBbacterialanti-TBInhibitorinhibitorinhibit

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