288-32-4
288-32-4
Chemical Structure
Imidazole
Synonym(s): Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
- No. CAS: 288-32-4
- Formula:C3H4N2
- Molecular Weight:68.08
IUPAC Name: 1H-imidazole
InChIKey: RAXXELZNTBOGNW-UHFFFAOYSA-N
SMILES: C1=NC=CN1
Biological Activity: Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Imidazole | 99.88% | Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Imidazole (Standard) | ≥98% | Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Imidazole-d4 | 99.94% | Imidazole-d4 is the deuterium labeled Imidazole. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Imidazole-15N2 | 98.56% | Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Oxazole | 99.98% | 1,3-Oxazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1H-pyrazole | 98.0% | 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally active antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1H-Imidazole hydrochloride | 99.96% | 1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Pyrazine | 99.97% | Pyrazine (1,4-Diazine) is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, and is well known for its electron-deficient property. Pyrazine serves as a key pharmacophore in a variety of drugs, and also acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic and anti-inflammatory activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ZIF-64 | ZIF-64 (1H-Imidazole, zinc salt) is a metal-organic framework (MOF). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,2,4-Triazole (Standard) | 99.99% | 1,2,4-Triazole (Standard) is the analytical standard of 1,2,4-Triazole. This product is intended for research and analytical applications. 1,2,4-Triazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,2,4-Triazole-13C2,15N3 | NSC 83128-13C2,15N3 is the 13C and 15N labeled NSC 83128. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2-Methylimidazole (Standard) | ≥98% | 2-Methylimidazole (Standard) is the analytical standard of 2-Methylimidazole. This product is intended for research and analytical applications. 2-Methylimidazole (2-Methyl-1H-imidazole) is a nitrogen-containing MOF ligand that serves as a laccase-mimicking activity enhancer and a morphology regulator for copper-based metal-organic frameworks. 2-Methylimidazole promotes the formation of natural laccase-like nanoenzyme structures, accelerates electron transfer and enhances catalytic activity. During hydrothermal synthesis, 2-Methylimidazole inhibits the vertical growth of crystals, thus enabling the preparation of two-dimensional nanosheet morphology. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Noriega-Iribe E, et al. In vitro and in silico screening of 2, 4, 5-trisubstituted imidazole derivatives as potential xanthine oxidase and acetylcholinesterase inhibitors, antioxidant, and antiproliferative agents[J]. Applied Sciences, 2020, 10(8): 2889.
- [2]. Ashish M. Kanhed, et al. Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2. Medicinal Chemistry Research, 2024 June 26, 1554-8120.
- [3]. Moncada S, et al. Imidazole: a selective inhibitor of thromboxane synthetase[J]. Prostaglandins. 1977 Apr;13(4):611-8. [Content Brief]
