536-33-4
536-33-4
Chemical Structure
Ethionamide
Synonym(s): 2-Ethylthioisonicotinamide
- CAS 番号: 536-33-4
- Formula:C8H10N2S
- Molecular Weight:166.25
IUPAC Name: 2-ethylpyridine-4-carbothioamide
InChIKey: AEOCXXJPGCBFJA-UHFFFAOYSA-N
SMILES: S=C(C1=CC(CC)=NC=C1)N
Biological Activity: Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity[1][2][3][4].
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Ethionamide | 99.98% | Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity. | ||||||||||||||||||||
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Ethionamide (Standard) | 99.91% | Ethionamide (Standard) is the analytical standard of Ethionamide. This product is intended for research and analytical applications. Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic. | ||||||||||||||||||||
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Ethionamide-d3 | Ethionamide-d3 is the deuterium labeled Ethionamide. Ethionamide (2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis. | |||||||||||||||||||||
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References
- [1]. Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277(15): p. 12824-9. [Content Brief]
- [2]. Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36(6): p. 1316-21. [Content Brief]
- [3]. Marilyn C Henderson, et al. Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7. [Content Brief]
- [4]. Amy L Palmer, et al. Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse. Pharmaceuticals (Basel). 2012;5(11):1147-59. [Content Brief]
