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Atf4 Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158202
    ATF4-IN-2

    		Others Neurological Disease
    ATF4-IN-2 (Compound 29) is a ATF4 inhibitor with a IC50 value of 47.71 nM. ATF4-IN-2 can be used in the study of neurodegenerative diseases .
    ATF4-IN-2
  • HY-158201
    ATF4-IN-1

    		Others Neurological Disease
    ATF4-IN-1 (Compound 21) is an ATF4 inhibitor. ATF4-IN-1 inhibits ATF4 expression in Thapsigargin (HY-13433)-stimulated HEK-293T cells, with an IC50 value of 32.43 nM. ATF4-IN-1 is more active than ISRIB (HY-12495A). ATF4-IN-1 exhibits low cytotoxicity (IC50: 96 μM against HEK-293T cells). ATF4-IN-1 can be used for research of neurodegenerative diseases .
    ATF4-IN-1
  • HY-158196
    PERK/eIF2α activator 1

    		PERK Apoptosis Cancer
    PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM .
    PERK/eIF2α activator 1
  • HY-158204
    CNB-001

    		Lipoxygenase Neurological Disease
    CNB-001 is a potent 5-lipoxygenase (5-LOX) inhibitor, decreases 5-LOX expression, and increases proteasome activity. CNB-001 also increases eIF2α phosphorylation and HSP90 and ATF4 levels in Alzheimer's disease transgenic mice, and limits the accumulation of soluble Aβ and ubiquitinated aggregated proteins. CNB-001 maintains the expression of synapse-associated proteins and improves memory. CNB-001 can be used for the research of Alzheimer's disease .
    CNB-001
  • HY-158205
    HPO-DAEE

    4-Hydroperoxy-2-decenoic acid ethyl ester

    		 Reactive Oxygen Species HDAC SOD Inflammation/Immunology Cancer
    HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways .
    HPO-DAEE

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