2752441-61-3
2752441-61-3
Chemical Structure
APL-4098
- CAS No.: 2752441-61-3
- Formula:C17H12ClFN6O3S
- Molecular Weight:434.83
InChIKey: ZHEOLZYPHNHWHG-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=N1)Cl)S(=O)(NC2=NC=CC(C#CC3=CN=C(N=C3)N)=C2F)=O
Biological Activity: APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. APL-4098 reduces the phosphorylation level of eIF2α and the expression level of ATF4. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia[1].
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APL-4098 | 99.84% | APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. APL-4098 reduces the phosphorylation level of eIF2α and the expression level of ATF4. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia. | ||||||||||||||||||||
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References
Keywords
