2991057-60-2
2991057-60-2
Chemical Structure
ATF4-IN-2
- CAS No.: 2991057-60-2
- Formula:C24H21BrClN5O4
- Molecular Weight:558.81
InChIKey: WWRGDZABEXNLFW-UHFFFAOYSA-N
SMILES: O=C(C1=NN=C(C2=CC=C(Br)C=C2)O1)NCC3CCN(NC(C4=CC5=CC(Cl)=CC=C5O4)=O)CC3
Biological Activity: ATF4-IN-2 is an ATF4 inhibitor with an IC50 of 47.71 nM. ATF4-IN-2 activates eIF2B, binds to the ISRIB (HY-12495A) binding pocket, restores protein translation, and inhibits ATF4 expression. ATF4-IN-2 inhibits ATF4 protein expression in Thapsigargin (HY-13433)-stimulated cells. ATF4-IN-2 can be used for research on neurodegenerative diseases[1].
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ATF4-IN-2 | 99.24% | ATF4-IN-2 is an ATF4 inhibitor with an IC50 of 47.71 nM. ATF4-IN-2 activates eIF2B, binds to the ISRIB (HY-12495A) binding pocket, restores protein translation, and inhibits ATF4 expression. ATF4-IN-2 inhibits ATF4 protein expression in Thapsigargin (HY-13433)-stimulated cells. ATF4-IN-2 can be used for research on neurodegenerative diseases. | ||||||||||||||||||||
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