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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
B0143
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "B0143" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: Nicotinic acid; Vitamin B3
12
12 Publications Verification
Synonyms: Nicotinic acid hydrochloride; Vitamin B3 hydrochloride
Category:
Alkaloids Ketones, Aldehydes, Acids Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-B0143S2
CAS No.: 66148-15-0
Synonyms: Nicotinic acid-d4; Vitamin B3-d4
Category:
Alkaloids Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite
Target:
Cat. No.: HY-B0143S3
CAS No.: 1189954-79-7
Synonyms: Nicotinic acid-13C6; Vitamin B3-13C6
Cat. No.: HY-B0143S4
CAS No.: 2483829-87-2
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b, and does not activate the mouse homologous receptor PUMA-G. GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol (HY-B0468)-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin (HY-B0143), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis .
Target:
Cat. No.: HY-W001996
CAS No.: 5006-66-6
Cat. No.: HY-W002864
CAS No.: 6311-35-9
Cat. No.: HY-W015793
CAS No.: 3167-49-5
Research Areas:
6-Aminonicotinic acid is an analog of Niacin (HY-B0143) and also a GABAA receptor agonist with a Ki value of 4.4 μM in rats. 6-Aminonicotinic acid binds to both native and recombinant GABAA receptors, is metabolized into non-functional pyridine nucleotide analogs to inhibit dehydrogenases, and suppresses the proliferation of T2 bacteriophages. 6-Aminonicotinic acid accumulates in specific bacterial cells in the form of pyridine nucleotide analog metabolites. 6-Aminonicotinic acid can be used in research related to neurological disorders such as anxiety, epilepsy and schizophrenia, and also serves as an intermediate in organic synthesis .
Cat. No.: HY-W001996R
CAS No.: 5006-66-6
Cat. No.: HY-W015467
CAS No.: 636-73-7
Synonyms: Pyridine-3-sulphonic acid
Cat. No.: HY-178935
CAS No.: 1099611-82-1
Research Areas:
α-Amylase-IN-14, a derivative of Nicotinic (HY-B0143), is an α-amylase inhibitor and has good interactions with α-amylase protein (-5.55 kcal/mol). α-Amylase-IN-14 is a dual anti-inflammatory and anti-hyperglycemic agent. α-Amylase-IN-14 exhibits good results against DPPH and ABTS radicals. α-Amylase-IN-14 can be used for the study of diabetes .
Cat. No.: HY-177738
CAS No.: 2102591-12-6
Target:
Research Areas:
6'Nicotinate Ac4ManNAz (Compound 2) is a brain-penetrant carbohydrate-neuroactive heteromer conjugating Ac4ManNAz (HY-W728531) and Nicotinic acid (HY-B0143). 6'Nicotinate Ac4ManNAz can be used for the development of glycosylation-regulating agents or diagnostic probes that cross the BBB .
Cat. No.: HY-113353R
CAS No.: 583-08-4
Target:
Cat. No.: HY-105020
CAS No.: 99518-29-3
Target:
Research Areas:
Derpanicate is a Nicotinic acid (HY-B0143) ester. Derpanicate has antihypercholesterolaemic and/or vasodilating effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
