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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
B7H4
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "B7H4" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-P99242
CAS No.: 2254029-91-7
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BD-9136 is a selective BRD4 PROTAC degrader with a DC50 of 1.2 nM, and exhibits a selectivity of ≥1000-fold over BRD2 and BRD3. BD-9136 preferentially forms a ternary complex with the BD1 domain of BRD4, and downregulates the expression of B7-H4 by disrupting the PR-P300-BRD4 axis. BD-9136 depletes BRD4 protein in tumor tissues, inhibits tumor growth, reduces B7-H4 protein expression, increases CD8+ T cell infiltration, and enhances tumor sensitivity to anti-PD-L1. Degradation of BRD4 by BD-9136 rescues the erythroid differentiation block induced by LSD1 inhibition, and transient administration restores erythroid output while retaining HbF induction. BD-9136 causes no adverse effects in mice at effective doses. BD-9136 can be used in studies related to acute myeloid leukemia, acute lymphoblastic leukemia and breast cancer .
Cat. No.: HY-171689
CAS No.: 2760250-80-2
Synonyms: AZD 8205; P-Sam
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Puxitatug samrotecan (AZD 8205) is a B7-H4-directed antibody-drug conjugate (ADC) bearing a Topoisomerase I inhibitor (TOP1i) payload. Puxitatug samrotecan improves HR +/HER2 - breast cancer .
Cat. No.: HY-P991703
CAS No.: 3042847-92-4
Synonyms: GSK5733584 antibody; HS-20089 antibody; hu2F7
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Cat. No.: HY-P990059
CAS No.: 2760250-47-1
Synonyms: INT-016; AZD8205 Antibody
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Cat. No.: HY-P990953
CAS No.: 2640279-10-1
Synonyms: Gen1047
Cat. No.: HY-177542
CAS No.: 2855974-40-0
Synonyms: Emi-Le; XMT-1660
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Emiltatug ledadotin (Emi-Le; XMT-1660) is a B7-H4-targeted antibody-drug conjugate (ADC). Emiltatug ledadotin consists of the tumor-specific anti-B7-H4 monoclonal antibody Emiltatug (HY-P990918) and the linker-payload system Ledadotin (HY-177541), with site-specific conjugation achieved via GlycoConnect click chemistry. Emiltatug ledadotin inhibits the growth of B7-H4-positive cancer cells. Emiltatug ledadotin can be used to study advanced solid tumors with B7-H4 overexpression, particularly breast cancer, ovarian cancer, and endometrial cancer .
Cat. No.: HY-P991223
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Cat. No.: HY-148696A
CAS No.: 2414254-49-0
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Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro .
Cat. No.: HY-RS15721
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VTCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for VTCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P990341
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Cat. No.: HY-P81427A
Synonyms: B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
Cat. No.: HY-185761
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ADC Control Human IgG1-rezetecan is an isotype-matched control antibody-drug conjugate (ADC) for Mocertatug rezetecan (HY-185280). Mocertatug rezetecan is an ADC targeting B7-H4 .
Cat. No.: HY-P704416
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4
Cat. No.: HY-P74395Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
