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Results for "

CASP1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

2

Natural
Products

3

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-171006
    IRF1-IN-1
    1 Publications Verification

    		 Caspase PARP Pyroptosis Interleukin Related IFNAR Infection Inflammation/Immunology
    IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury [1].
    IRF1-IN-1
  • HY-N0842
    Bevirimat
    2 Publications Verification

    PA-457; MPC-4326; YK FH312

    		 Virus Protease Infection
    Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies [1] .
    Bevirimat
  • HY-171007
    IRF1-IN-2
    1 Publications Verification

    		 Caspase PARP Pyroptosis Interleukin Related Glutathione Peroxidase IFNAR Infection Inflammation/Immunology
    IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury [1].
    IRF1-IN-2
  • HY-RS01942
    Casp1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Casp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Casp1 Mouse Pre-designed siRNA Set A
    Casp1 Mouse Pre-designed siRNA Set A
  • HY-RS01941
    CASP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CASP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CASP1 Human Pre-designed siRNA Set A
    CASP1 Human Pre-designed siRNA Set A
  • HY-RS01943
    Casp1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Casp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Casp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Casp1 Rat Pre-designed siRNA Set A
    Casp1 Rat Pre-designed siRNA Set A
  • HY-150536
    EP39

    		HIV HIV Protease Infection
    EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity [1].
    EP39
  • HY-N0842R
    Bevirimat (Standard)

    PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)

    		 Reference Standards Virus Protease Infection
    Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].
    Bevirimat (Standard)
  • HY-179348
    DPP9-IN-2

    		Dipeptidyl Peptidase HIV Pyroptosis Cancer
    DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC50 of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection [1].
    DPP9-IN-2
  • HY-183739
    CQ31

    		Pyroptosis Caspase Cancer
    CQ31 is a PEPD and XPNPEP1 inhibitor, with an IC50 of 0.67 μM against PEPD and an IC50 of 122 μM against XPNPEP1. CQ31 inhibits the M24B aminopeptidase activity of PEPD and XPNPEP1. CQ31 induces the accumulation of Xaa-Pro-containing peptides, mildly inhibits DPP8/9, and triggers CASP1-dependent pyroptosis via activation of the CARD8 inflammasome and caspase-1. CQ31 can be used in research related to cancers such as acute myeloid leukemia [1] .
    CQ31
  • HY-181132
    dCASP1-55

    		PROTACs Caspase NF-κB Apoptosis Cancer
    dCASP1-55 is a cereblon-dependent caspase-1 (CASP1) PROTAC degrader. dCASP1-55 induces excessive NF-κB activation, apoptosis, and moderate S-phase arrest in leukemic cells. dCASP1-55 suppresses colony formation of leukemic cells. dCASP1-55 can be used for the research of cancer, such as myeloid malignancies and acute myeloid leukemia [1].
    dCASP1-55
  • HY-P11596
    NOTA-Asp2-αvβ6L

    		Integrin Cancer
    NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) [1].
    NOTA-Asp2-αvβ6L

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