66 Results for "

CD+38

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "CD+38" in MCE Product Catalog:

12
CD38 inhibitor 1
CD38 inhibitor 1
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12 Publications Verification
Cat. No.: HY-123999
CAS No.: 1700637-55-3
Purity:  99.26%
Target:  

CD38

Research Areas:  

Metabolic Disease

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38 .
11
Daratumumab
Daratumumab
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11 Cited Publications
Cat. No.: HY-P9915
CAS No.: 945721-28-8
Synonyms: Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414

Target:  

CD38 ADC Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
11
Daratumumab (Anti-CD38)
Daratumumab (Anti-CD38)
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11 Cited Publications
Cat. No.: HY-P9915A
CAS No.: 945721-28-8
Synonyms: Anti-Human CD38, Human Antibody (PBS)

Target:  

ADC Antibodies CD38

Research Areas:  

Cancer

Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
10
Kuromanin chloride
Kuromanin chloride
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10 Cited Publications
Cat. No.: HY-N0640
CAS No.: 7084-24-4
Synonyms: Chrysontemin; Cyanidin 3-O-glucoside chloride
Category:  

Anthocyans Flavonoids Microorganisms Metabolic Disease Phenols Polyphenols Plants Moraceae Disease Research Fields Morus alba Linn.

Target:  

CD38

Kuromanin chloride (Chrysontemin) is derived from mulberry leaves and has the effect of increasing blood sugar concentration and maintaining lipid metabolism balance to reduce obesity. Kuromanin chloride can inhibit CD38 enzymatic activities .
7
Sulfo-ara-F-NMN
Sulfo-ara-F-NMN
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7 Cited Publications
Cat. No.: HY-129522
CAS No.: 1374663-29-2
Purity:  99.18%
Synonyms: CZ-48
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Neurological Disease

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .
1
Isatuximab
Isatuximab
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1 Cited Publications
Cat. No.: HY-P9976
CAS No.: 1461640-62-9
Synonyms: ch38SB19; hu38SB19; SAR-650984

Target:  

CD38 Apoptosis

Research Areas:  

Cancer

Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .
1
MK-0159
MK-0159
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1 Cited Publications
Cat. No.: HY-150508
CAS No.: 2641484-61-7
Purity:  98.60%
Target:  

CD38

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD + (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .
1
Isatuximab (anti-CD38)
Isatuximab (anti-CD38)
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1 Cited Publications
Cat. No.: HY-P9976A
CAS No.: 1461640-62-9

Target:  

CD38 Apoptosis

Research Areas:  

Cancer

Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions .
1
RBN013209
RBN013209
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1 Cited Publications
Cat. No.: HY-144987
CAS No.: 2597933-17-8
Purity:  98.84%
Target:  

CD38 LAG-3 Tim3 PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

RBN013209 is an orally active small molecule inhibitor of CD38 with an IC50 of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD + to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .
1
Luteolinidin chloride
Luteolinidin chloride
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1 Cited Publications
Cat. No.: HY-129997
CAS No.: 1154-78-5
Purity:  99.73%
Category:  

Anthocyans Sorghum bicolor (Linn.) Moench Flavonoids Gramineae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

CD38 NADPH Oxidase Tyrosinase

Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin .
1
Mezagitamab
Mezagitamab
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1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .
Felzartamab
Felzartamab
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Cat. No.: HY-P99616
CAS No.: 2197112-39-1
Synonyms: MOR-202

Target:  

CD38

Research Areas:  

Cancer

Felzartamab (MOR-202) is a human monoclonal antibody that targets CD38 and can be used in multiple myeloma research .
Anti-Mouse CD38 Antibody (NIMR5)
Anti-Mouse CD38 Antibody (NIMR5)
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Cat. No.: HY-P990273

Target:  

CD38 ERK CD1 Apoptosis

Research Areas:  

Cancer

Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38 IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer .
ISB2001
ISB2001
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Cat. No.: HY-P991490

Target:  

CD38 CD3 TNF Receptor

Research Areas:  

Cancer

ISB2001 is a trispecific antibody targeting CD38, CD3 and BCMA. ISB2001 effectively counteracts tumor immune escape mechanisms caused by antigen downregulation, antigen loss, soluble factor competition and other factors. ISB2001 is applicable to relevant research on multiple myeloma and relapsed/refractory multiple myeloma .
Modakafusp alfa
Modakafusp alfa
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Cat. No.: HY-P99744
CAS No.: 2254522-19-3
Synonyms: TAK-573

Target:  

CD38

Research Areas:  

Inflammation/Immunology Cancer

Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to CD38-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice .
CD38 inhibitor 2
CD38 inhibitor 2
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Cat. No.: HY-144988
CAS No.: 2597933-78-1
Purity:  98.81%
Target:  

CD38

Research Areas:  

Cancer

CD38 inhibitor 2 is a potent CD38 inhibitor (IC50 = 0.01 ~ 0.1 μΜ).
Ara-F-NAD+ sodium
Ara-F-NAD+ sodium
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Cat. No.: HY-134358A
Purity:  99.81%
Target:  

CD38

Research Areas:  

Neurological Disease

Ara-F-NAD+ sodium is an arabino analogue of NAD +. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .
SAR-442257
SAR-442257
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Cat. No.: HY-P991183

Target:  

CD28 CD38 CD3

Research Areas:  

Cancer

SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .
17-HDHA
17-HDHA
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Cat. No.: HY-113512
CAS No.: 90780-52-2
Purity:  98.8%
Target:  

Influenza Virus

Research Areas:  

Inflammation/Immunology

17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 + CD38 + antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .
Cd38 Mouse Pre-designed siRNA Set A
Cd38 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS02240
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Cd38 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd38 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Assay Types