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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and *HIF-1α* signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and *Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β* and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders ^[1] .

HY-B0623A

Ropinirole hydrochloride 3 Publications Verification SKF 101468 hydrochloride	Dopamine Receptor	Neurological Disease
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease ^[1] .

HY-125527

Resolvin D1 1 Publications Verification RvD1	Endogenous Metabolite	Inflammation/Immunology
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages ^[1] .

HY-N0034

Arctiin 5 Publications Verification Arctii; NSC 315527; Arctigenin-4-glucoside	NF-κB	Inflammation/Immunology Cancer
Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in ammatory cytokines levels. Arctiin can used in study glomerulonephritis .

HY-112624A

Dextran T1 (MW 1,000) Dextran 1; Dextran D1; Dextran T1(MW 800-1200)	Biochemical Assay Reagents	Others
Dextran T1 (Dextran 1; Dextran D1) (with a molecular weight of 1,000) is a dehydrated glucose polymer with an average molecular weight of 1,000. Dextran T1 (MW 1,000) has excellent biodegradability and biocompatibility, and can be used as a nanobody carrier scaffold and a freeze-drying protectant. Dextran T1 (MW 1,000) promotes the retention of circulating tumor cells in the capillary bed ^[1] .

HY-10435A

SKF-82958 hydrobromide 4 Publications Verification (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM) ^[1].

HY-B0892S4

Benzyl alcohol-d1 Benzenemethanol-d₁	Endogenous Metabolite	Others
Benzyl alcohol-d₁ is the deuterium labeled Benzyl alcohol ^[1].

HY-111428

Phleomycin D1 2 Publications Verification PLM D1	Antibiotic	Infection
Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase ^[1] .

HY-106094

CY 208-243 2 Publications Verification	Dopamine Receptor	Neurological Disease
CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity ^[1].

HY-101299B

Dihydrexidine hydrochloride 5 Publications Verification DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy **D1-like dopamine receptor (D1/D5) agonist, with an IC₅₀** of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity ^[1] . Dihydrexidine hydrochloride can stimulate YAP phosphorylation .

HY-115553

DETQ	Dopamine Receptor	Neurological Disease
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC₅₀ of 5.8 nM and a K_b of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor ^[1].

HY-125527A

17(R)-Resolvin D1 1 Publications Verification 17(R)-RvD1; AT-RvD1	TRP Channel	Inflammation/Immunology
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells ^[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT	Inflammation/Immunology
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, *COX-1* inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers ^[1] .

HY-W025916

Methanol-d1	Isotope-Labeled Compounds	Others
Methanol-d₁ is the deuterium labeled Methanol.

HY-120458

LCAHA 1 Publications Verification LCA hydroxyamide	Deubiquitinase	Cancer
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC₅₀s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a ^[1].

HY-P11147

IL13Rα2 D1	Interleukin Related FAK Src Akt ERK MMP	Cancer
IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor. IL13Rα2 D1 can inhibit IL-13-induced cell adhesion, migration, invasion, and proliferation. IL13Rα2 D1 can inhibit FAK, Src, AKT, ERK1/2 phosphorylation, and MMP expression. IL13Rα2 D1 can be used for research on cancers such as colorectal cancer ^[1].

HY-159527

Glovadalenum Glovadalen	Dopamine Receptor	Neurological Disease
Glovadalenum (Glovadalen) is an orally active, selective, blood-brain barrier permeable positive allosteric modulator of dopamine D1 receptor. Glovadalenum selectively enhances the efficacy of dopamine in activating dopamine D1 receptor. Glovadalenum can be used for the research of Parkinson's disease ^[1].

HY-125527S

Resolvin D1-d5 RvD1-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages ^[1] .

HY-103427

NPEC-caged-dopamine	Dopamine Receptor	Neurological Disease
NPEC-caged-dopamine is a caged version of dopamine. NPEC-caged-Dopamine was used by applying focal photolysis with UV light (360 nm) to releases dopamine, which leads to D1 receptor activation ^[1].

HY-147651

β-catenin-IN-4	β-catenin CDK c-Myc	Cancer
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc ^[1].

HY-101299A

Dihydrexidine DAR-0100	Dopamine Receptor YAP	Neurological Disease
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy **D1-like dopamine receptor (D1/D5) agonist with an IC₅₀** of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity ^[1] . Dihydrexidine can stimulate YAP phosphorylation .

HY-128031

Resolvin D1 methyl ester RvD1 methyl ester	Drug Derivative	Metabolic Disease
Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels ^[1].

HY-113096

Prostaglandin D1 PGD1	Endogenous Metabolite	Metabolic Disease
Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC₅₀ value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research ^[1] .

HY-P10405A

TAT-D1 peptide acetate	Dopamine Receptor	Neurological Disease
TAT-D1 peptide acetate is a dopamine *D1-D2* receptor heterodimer inhibitor. TAT-D1 peptide acetate disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide acetate produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide acetate can be used in the research of psychostimulant addiction, depression and anxiety disorders ^[1] .

HY-W020018S1

N-Methylacetamide-d1	Isotope-Labeled Compounds	Others
N-Methylacetamide-d₁ is the deuterium labeled N-Methylacetamide ^[1].

HY-103380

NSC 625987 1 Publications Verification	CDK	Cancer
NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC₅₀ of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2 ^[1].

HY-W016577S4

1-Bromoheptane-d1 n-Heptyl bromide-d₁	Isotope-Labeled Compounds	Others
1-Bromoheptane-d₁ is the deuterium labeled 1-Bromoheptane ^[1].

HY-144291

LY3154885	Dopamine Receptor	Neurological Disease
LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile ^[1].

HY-145119S

Mindeudesivir VV116 free base; GS-621763-D1	Isotope-Labeled Compounds	Others
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) ^[1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-170645

Neuroprotectin D1 methyl ester	Drug Intermediate	Neurological Disease
Neuroprotectin D1 methyl ester is an esterified form of Protectin D1 (HY-130413). Neuroprotectin D1 methyl ester is an intermediate in the synthesis of Protectin D1.

HY-N14076

Monamycin D1	Antibiotic Bacterial	Infection
Monamycin D1 is an ester peptide antibiotic. Monamycin D1 has activity against Gram-positive bacteria ^[1].

HY-N15531

Icariside D1	Estrogen Receptor/ERR	Inflammation/Immunology Cancer
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers ^[1].

HY-N16465

Cinnamtannin D1	Apoptosis Reactive Oxygen Species (ROS) STAT	Inflammation/Immunology
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) ^[1] .

HY-163373

13,14-Dihydro-15-keto prostaglandin D1	Drug Derivative	Endocrinology
13,14-Dihydro-15-keto prostaglandin D1 is a derivative of prostaglandin D1 ^[1].

HY-N12295

Ciwujianoside D1	Others	Inflammation/Immunology
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells ^[1].

HY-134860

Prostaglandin D1 alcohol	Prostaglandin Receptor	Metabolic Disease
Prostaglandin D1 (PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl ^[1].

HY-N15115

Polymyxin D1	Antibiotic Bacterial	Infection
Polymyxin D1 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria ^[1].

HY-P10405

TAT-D1 peptide	Dopamine Receptor	Neurological Disease
TAT-D1 peptide is a dopamine *D1-D2* receptor heterodimer inhibitor. TAT-D1 peptide disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide can be used in the research of psychostimulant addiction, depression and anxiety disorders ^[1] .

HY-W865379

(S)-Avadomide-d1 SP-3164; CC 122-d₁	Isotope-Labeled Compounds	Others
(S)-Avadomide-d₁ (SP-3164; CC 122-d₁) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).

HY-W016174S

Diphenylsulfane-d1	Isotope-Labeled Compounds	Others
Diphenylsulfane-d₁ is the deuterium labeled Diphenylsulfane ^[1].

HY-W712650

Triethylsilane-d1	Isotope-Labeled Compounds	Others
Triethylsilane-d₁ is deuterium labeled Triethylsilicon hydride ^[1].

HY-175001

D1/D5 Receptor agonist-1	Dopamine Receptor Arrestin	Neurological Disease
D1/D5 Receptor agonist-1 is a highly brain-penetrant and orally active D1/D5 receptor agonist. D1/D5 Receptor agonist-1 maintains considerable efficacy in the cAMP pathway and in β-arrestin recruitment, with EC₅₀s of 3.7 nM (D1R cAMP), 91 nM (D1R β-arrestin), 129 nM (D1R internalization) and a K_i of 111 nM (D1R binding affinity). D1/D5 Receptor agonist-1 inhibits β-arrestin signaling in a rat with L-DOPA (HY-N0304) induced dyskinesias. D1/D5 Receptor agonist-1 can be used for the study of Parkinson’s disease ^[1].

HY-109037S2

Mavacamten-d1 MYK461-d₁; SAR439152-d₁	Isotope-Labeled Compounds Myosin	Cardiovascular Disease
Mavacamten-d₁ (MYK461-d₁; SAR439152-d₁) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-W014292S

3-Benzyloxybenzaldehyde-α-d1	Isotope-Labeled Compounds	Others
3-Benzyloxybenzaldehyde-α-d₁ is the deuterium labeled 3-Benzyloxybenzaldehyde ^[1].

HY-W400722

Sodium 3-methyl-2-oxobutanoate-13C5,d1	Isotope-Labeled Compounds	Others
Sodium 3-methyl-2-oxobutanoate- ¹³C₅,d₁ is the deuterium and ¹³C labeled Sodium 3-methyl-2-oxobutanoate ^[1].

HY-10435

SKF-82958 (±)-SKF-82958; Chloro-APB	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM) ^[1].

HY-172750

17(R,S)-Benzo-resolvin D1 17(R,S)-Benzo-RvD1	Drug Derivative	Inflammation/Immunology
17(R,S)-Benzo-resolvin D1 (17(R,S)-Benzo-RvD1) is a Resolvin D1 (HY-125527) analogue with pro-resolving and anti-migratory activity. 17(R,S)-Benzo-resolvin D1 attenuates neointimal hyperplasia in a rat model of acute vascular injury ^[1].

HY-N17347

(25S)-Pratioside D1	HIV	Infection
(25S)-Pratioside D1 is a spirostanol saponin that can be found in the rhizomes of Aspidistra typica Baill. (25S)-Pratioside D1 can be used for the research of *HIV-1* infection ^[1].

HY-103411

SKF83822 hydrobromide	Dopamine Receptor	Neurological Disease
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates G_s/_olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors ^[1].

HY-145474

17(R)-Resolvin D1 methyl ester	Endogenous Metabolite	Inflammation/Immunology
17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC₅₀ approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1 ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and *HIF-1α* signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and *Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β* and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders ^[1] .

HY-15128

9-cis-Retinoic acid 5 Publications Verification Alitretinoin	Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities ^[1] .

HY-107738

Guggulsterone Maximum Cited Publications 21 Publications Verification Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, *xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* ^[1] . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-76542

Vitamin D2 4 Publications Verification Ergocalciferol; Calciferol; Ercalciol	Structural Classification Human Gut Microbiota Metabolites other families Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids Source Classification	Environmental Pollutants Endogenous Metabolite VD/VDR
Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D .

HY-125527

Resolvin D1 1 Publications Verification RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages ^[1] .

HY-N0034

Arctiin 5 Publications Verification Arctii; NSC 315527; Arctigenin-4-glucoside	Structural Classification Classification of Application Fields Anti-aging Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Disease Research Fields Source Classification Cancer	NF-κB
Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in ammatory cytokines levels. Arctiin can used in study glomerulonephritis .

HY-N1411

Platycodin D 5+ Cited Publications	Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	AMPK Wnt
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N0028

Forsythiaside A 5 Publications Verification	Oleaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D .

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Corydalis yanhusuo W. T. Wang Plants Isoquinoline Alkaloids Papaveraceae Source Classification	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of *5-HT_1A* with an IC₅₀ of 370 nM.

HY-18981

Decursin 2 Publications Verification (+)-Decursin	Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	PKC Apoptosis CXCR
Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities ^[1] .

HY-N0815

Resibufogenin 5+ Cited Publications Bufogenin; Recibufogenin	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	PI3K Akt NF-κB AP-1 GSK-3 CDK
Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt, NF-κB, *AP-1, activates GSK-3β, and regulates cyclin D1*. Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer, colorectal cancer, pancreatic cancer, and glioma ^[1] .

HY-113114

Tetrahydrocortisone	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Glucocorticoid Receptor
Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5_β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status ^[1].

HY-N0482

Phillyrin 5+ Cited Publications	Infection Oleaceae Classification of Application Fields Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat *CYP1A2* and *CYP2D1* activities, without affecting CYP2C11 and CYP3A1/2 activities ^[1]. Phillyrin has anti-influenza A virus activities .

HY-112023

Lumisterol 3 (purity>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-N15721

Tryptophan-cholic acid Trp-CA	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Orphan GPCR GLP Receptor
Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-conjugated bile acid that acts as an endogenous ligand and agonist (EC₅₀=9.6 μM) for the orphan G protein-coupled receptor (GPCR) MRGPRE (Mas-related G protein-coupled receptor family member E). Tryptophan-cholic acid is orally effective but has poor oral absorption and does not cross the blood-brain barrier. Tryptophan-cholic acid promotes the secretion of glucagon-like peptide GLP-1, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid improves glucose tolerance, promotes insulin secretion, and alleviates high-fat diet-induced hepatic steatosis without causing pruritus side effects. Tryptophan-cholic acid is primarily used in research on type 2 diabetes (T2D) .

HY-N6715

Tenuazonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer ^[1] .

HY-N4327

Eurycomalactone	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Apoptosis Akt Bcl-2 Family
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) ^[1] .

HY-103382

Arcyriaflavin A	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Indole Alkaloids Source Classification	Fungal
Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor. Arcyriaflavin A exists in the marine ascidian Eudistoma sp. and the slime mold Arcyria denudata. Arcyriaflavin A is applicable to research related to colon cancer and lung cancer ^[1] .

HY-N6953

Garcinone D 4 Publications Verification	Xanthones Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Source Classification	STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)
Garcinone D is an activator of the STAT3/Cyclin D1 and *Nrf2/HO-1* pathways, and an inhibitor of *CDK2/CyclinE1* (IC₅₀ for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer ^[1] .

HY-116514

(S)-(−)-Perillyl alcohol	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Labiatae Plants Endogenous metabolite Dolichos trilobus Houtt. Disease Research Fields Source Classification Cancer	Farnesyl Transferase Apoptosis Endogenous Metabolite
(S)-(-)-Perillyl alcohol, a monoterpene, is an orally active farnesyl transferase and geranylgeranyl transferase inhibitor. (S)-(-)-Perillyl alcohol up-regulates the mannose-6-phosphate receptor, facilitating *TGF-β1* activation and cytostasis,. (S)-(-)-Perillyl alcohol induces apoptosis in cancer cells, modulates cyclin D1 and *AP-1* activity. (S)-(-)-Perillyl alcohol exhibits antitumor activity against sarcoma tumors in mice. (S)-(-)-Perillyl alcohol can be used for the research of squamous cell carcinoma of the esophagus and sarcoma 180 ^[1] .

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Plants Isoquinoline Alkaloids Menispermaceae Source Classification	Dopamine Receptor
L-Stepholidine (Stepholidine) is an alkaloid. L-Stepholidine exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect. L-Stepholidine can be used for the researches of neurological disease, such as Parkinson disease, Alzheimer's disease and opiate addiction ^[1] .

HY-N7045

Isosilybin B 2 Publications Verification	Flavanonols Flavonoids Glycine soya Classification of Application Fields Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Source Classification Cancer	Androgen Receptor Apoptosis CDK Caspase PSMA
Isosilybin B is a flavonolignan. Isosilybin B can be isolated from Silybum marianum. Isosilybin B can regulate cell cycle-related proteins (e.g., reduce cyclins (D3, D1, A, E), Cdk4, Cdk2, Cdc25A), and activate Caspases (Caspase-9 and Caspase-3). Isosilybin B can promote Apoptosis, reduce androgen receptor (AR) and PSA. Isosilybin B has anticancer activity against prostate cancer ^[1] .

HY-N0858

Gomisin G 2 Publications Verification	Infection Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification	HIV
Gomisin G is a lignin from S. chinesis with anti-HIV (EC₅₀ = 0.006 μg/mL), anti-liver cancer and anti-inflammatory activities. Gomisin G has an AKT-cyclin D1 dependent mechanism against triple-negative breast cancer (TNBC) cells through suppressing phosphorylation rather than inducing apoptosis. Gomisin G can inhibit AKT phosphorylation. Gomisin G can cause cell cycle arrest in the G1 phase. Gomisin G can be studied in research for diseases such as HIV, breast and liver cancers ^[1] .

HY-N2003

D-Tetrahydropalmatine 1 Publications Verification	Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis ^[1]. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, *COX-1* inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers ^[1] .

HY-N5140

Bacopaside X Bacopaside VII	Triterpenes Classification of Application Fields Terpenoids Other Diseases Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification	Dopamine Receptor
Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer ^[1].

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Dopamine Receptor
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research ^[1] .

HY-N6774

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-135525

Agroclavine	Infection Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification Cancer	Dopamine Receptor Adrenergic Receptor
Agroclavine acts as an agonist of the D1-dopamine receptor and α₁-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation ^[1] .

HY-N8549A

5-Dihydrocortisone	Classification of Application Fields Cardiacglycosides Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver ^[1]

HY-119833

Rubone	Chalcones Flavonoids Leguminosae Plants Source Classification Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets ^[1] .

HY-N14076

Monamycin D1	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
Monamycin D1 is an ester peptide antibiotic. Monamycin D1 has activity against Gram-positive bacteria ^[1].

HY-N15531

Icariside D1	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Estrogen Receptor/ERR
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers ^[1].

HY-N16465

Cinnamtannin D1	Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume Source Classification	Apoptosis Reactive Oxygen Species (ROS) STAT
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) ^[1] .

HY-N6715R

Tenuazonic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer ^[1] .

HY-N12295

Ciwujianoside D1	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Others
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells ^[1].

HY-N15115

Polymyxin D1	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Polymyxin D1 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria ^[1].

HY-N17347

(25S)-Pratioside D1	Structural Classification Aspidistra typica Baill. Plants Steroids Asparagaceae Juss. Source Classification	HIV
(25S)-Pratioside D1 is a spirostanol saponin that can be found in the rhizomes of Aspidistra typica Baill. (25S)-Pratioside D1 can be used for the research of *HIV-1* infection ^[1].

HY-N3945R

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Alkaloids Structural Classification other families Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae Source Classification	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities ^[1] .

HY-N4308

Hexamethylquercetagetin Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	NF-κB IKK Bcl-2 Family
Hexamethylquercetagetin (Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone) is an orally active NF-κB inhibitor. Hexamethylquercetagetin inhibits NF-κB-derived luciferase activity, reduces phosphorylated p65 and IκBα, Cyclin D1, Bcl-2 and blocks TNFα-induced NF-κB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma ^[1] .

HY-107738R

Guggulsterone (Standard) Z/E-Guggulsterone (Standard)	Triterpenes Structural Classification Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, *xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR)* antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

HY-129482

Detoxin D1	Natural Products Microorganisms Source Classification	Others
Detoxin D1 is a compound with antihistamine activity and a new type of H1 antagonist. In the suppression of seasonal allergic rhinitis, a daily dose of 10-30 mg has an equivalent and highly effective inhibitory effect compared with placebo and has good safety.

HY-N0034R

Arctiin (Standard) Arctii (Standard); NSC 315527 (Standard); Arctigenin-4-glucoside (Standard)	Structural Classification Natural Products Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Source Classification	Reference Standards NF-κB
Arctiin (Standard) is the analytical standard of Arctiin. This product is intended for research and analytical applications. Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in?ammatory cytokines levels. Arctiin can used in study glomerulonephritis .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N1411R

Platycodin D (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Endogenous metabolite Source Classification	Reference Standards AMPK Wnt
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N5140R

Bacopaside X (Standard) Bacopaside VII (Standard)	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Reference Standards Dopamine Receptor
Bacopaside X (Standard) is the analytical standard of Bacopaside X. This product is intended for research and analytical applications. Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

HY-B1131R

Taurocholic acid sodium salt hydrate (Standard) Sodium taurocholate hydrate (Standard); N-Choloyltaurine sodium salt hydrate (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia ^[1] .

HY-130285

10(S),17(S)-DiHDHA 10(S),17(S)-DiHDoHE; PDX	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
10(S),17(S)-DiHDHA (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities ^[1] .

HY-129694

Lenoremycin Ro 21-6150; Antibiotic A-130-A	Microorganisms Antibiotics Other Antibiotics Source Classification	β-catenin CDK Reactive Oxygen Species (ROS)
Lenoremycin (Ro 21-6150) is a microbial metabolite. Lenoremycin decreases β-catenin and cyclin D1 proteins levels. Lenoremycin decreases cancer stem cells (CSCs) populations via inducing reactive oxygen species production ^[1].

Cat. No.	Product Name	Chemical Structure

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 ^[1] .

HY-B0892S4

Benzyl alcohol-d1
Benzyl alcohol-d₁ is the deuterium labeled Benzyl alcohol ^[1].

HY-N0322S7

Cholesterol-d1

Cholesterol-d1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[1] . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W025916

Methanol-d1
Methanol-d₁ is the deuterium labeled Methanol.

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base ^[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-N0830S18

Palmitic acid-d1
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells ^[1] .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer ^[1] .

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages ^[1] .

HY-N7092S11

D-Fructose-d-1
D-Fructose-d-1 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants ^[1].

HY-14541S

Olanzapine-d3
Olanzapine-d₃ (LY170053-d₃) is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic ^[1] .

HY-W020018S1

N-Methylacetamide-d1
N-Methylacetamide-d₁ is the deuterium labeled N-Methylacetamide ^[1].

HY-W016577S4

1-Bromoheptane-d1
1-Bromoheptane-d₁ is the deuterium labeled 1-Bromoheptane ^[1].

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) ^[1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-B0389S4

D-Glucose-d1-2
D-Glucose-d₁-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response ^[1].

HY-W088065S1

Sodium formate-13C,d1

Sodium formate- ¹³C,d₁ is the deuterium and ¹³C labeled Sodium formate.Sodium formate is a biochemical assay reagent. Sodium formate can react with zinc sources (such as ZnCl₂) on the surface of alpha alumina support to form a zinc oxide layer. Sodium formate acts as a deprotonating agent, promoting the deprotonation of ligands (such as 2-methylimidazole) at high temperatures. Sodium formate provides the required reducing force in the catalytic oxidation of methane to methanol by methane monooxygenase (sMMO) and inhibits further oxidation of methanol ^[1] .

HY-W865379

(S)-Avadomide-d1
(S)-Avadomide-d₁ (SP-3164; CC 122-d₁) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).

HY-W016174S

Diphenylsulfane-d1
Diphenylsulfane-d₁ is the deuterium labeled Diphenylsulfane ^[1].

HY-W712650

Triethylsilane-d1
Triethylsilane-d₁ is deuterium labeled Triethylsilicon hydride ^[1].

HY-109037S2

Mavacamten-d1
Mavacamten-d₁ (MYK461-d₁; SAR439152-d₁) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-B0389S20

D-Glucose-13C,d-1
D-Glucose- ¹³C,d-1 is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si

HY-W014292S

3-Benzyloxybenzaldehyde-α-d1
3-Benzyloxybenzaldehyde-α-d₁ is the deuterium labeled 3-Benzyloxybenzaldehyde ^[1].

HY-W400722

Sodium 3-methyl-2-oxobutanoate-13C5,d1
Sodium 3-methyl-2-oxobutanoate- ¹³C₅,d₁ is the deuterium and ¹³C labeled Sodium 3-methyl-2-oxobutanoate ^[1].

HY-A0163S

Zuclopenthixol-d4 succinate salt
Zuclopenthixol-d₄ succinate is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist ^[1] .

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin- ¹³C₂,d₁ (Mixture of Diastereomers) is a ¹³C and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS ^[1].

HY-12987S

Pimozide-d4
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 ^[1] .

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 ^[1] .

HY-17637S2

Lumateperone-d4

Lumateperone-d₄ (ITI-007-d₄) is deuterium labeled Lumateperone. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used for the study of schizophrenia and bipolar depression ^[1] .

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-A0007S

Rotigotine-d7 hydrochloride

Rotigotine-d₇ (N-0923-d₇) hydrochloride is the deuterium labeled Rotigotine(HY-75502). Rotigotine is a potent dopamine receptor agonist with K_i values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer ^[1] .

HY-165645

Protectin D1-d5
Protectin D1-d₅ (Neuopotecti D1-d₅) is deuterium labeled Protectin D1 ^[1].

HY-113096S

Prostaglandin D1-d4
Prostaglandin D1-d₄ (PGD1-d₄) is deuterium labeled Prostaglandin D1. Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC₅₀ value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research ^[1] .

HY-151122S

Methylacetylene-d1
Methylacetylene-d₁ is the deuterium labeled Methylacetylene ^[1]. Methylacetylene-d1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 ^[1].

HY-W008841S3

N-Methylformamide-d1
N-Methylformamide-d₁ is the deuterium labeled N-Methylformamide ^[1].

HY-16504S

Treprostinil-13C2-d1 Sodium
Treprostinil- ¹³C₂-d₁ (Sodium) (UT-15- ¹³C₂-d₁(sodium)) is deuterium and ¹³C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent *DP1* and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-125527AS

17(R)-Resolvin D1-d5
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells ^[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-13956A

(R)-Pioglitazone-d1
(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.

HY-W018772S7

D-Ribose-d-1
D-Ribose-d-1 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g

HY-N0210S6

D-Galactose-d1-1
D-Galactose-d-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.

HY-I0960S7

Uracil-d1
Uracil-d₁ is the deuterium labeled Uracil ^[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-150628S

2-Oxobutanoic acid-13C,d1 sodium hydrate
2-Oxobutanoic acid- ¹³C,d₁ sodium hydrate is the deuterium and ¹³C labeled 2-Oxobutanoic acid sodium hydrate.

HY-125818S2

Cytidine-5'-triphosphate-13C,d1 dilithium

Cytidine-5'-triphosphate- ¹³C,d₁ (Cytidine triphosphate- ¹³C,d₁ dilithium; 5'-CTP- ¹³C,d₁) dilithium is deuterium and ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

HY-W048482S

rU Phosphoramidite-13C2,d1
rU Phosphoramidite- ¹³C₂,d₁ (DMT-2'O-TBDMS-rU phosphoramidite- ¹³C₂,d₁) is deuterium and ¹³C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W006550S1

2-Phenoxy-1-phenylethanol-d1
2-Phenoxy-1-phenylethanol-d₁ is the deuterium labeled 2-Phenoxy-1-phenylethanol (HY-W006550) ^[1].

HY-N0486S11

L-Leucine-d1
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway ^[1].

HY-W012850S1

DL-Cysteine-d1
DL-Cysteine-d₁ is the deuterated labeled 2-Amino-3-mercaptopropanoic acid (HY-W012850). 2-Amino-3-mercaptopropanoic acid is a cysteine derivative ^[1] .

HY-N0717S8

L-Valine-d1

L-Valine-d₁ ((S)-Valine-d₁) is the deuterium labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase ^[1] .

HY-W042357S3

Ac-rC Phosphoramidite-13C2,d1
Ac-rC Phosphoramidite- ¹³C₂,d₁ is deuterium and ¹³C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).

HY-W042357S5

Ac-rC Phosphoramidite-13C,d1
Ac-rC Phosphoramidite- ¹³C,d₁ is deuterium and ¹³C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).

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