3 Results for "

Diphyllin

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Diphyllin" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N2532
CAS No.: 22055-22-7
Diphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition), thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .
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Cat. No.: HY-N9351
CAS No.: 30021-77-3
Synonyms: Diphyllin O-glucoside
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .
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Cat. No.: HY-161691
Target:  

Filovirus

Research Areas:  

Infection

EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC50 of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC50 of 107 nM .
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