57 Results for "

Efficient delivery

" in MedChemExpress (MCE) Product Catalog:
Products (57)

57 Results for "Efficient delivery" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-138171
CAS No.: 2089251-33-0
Purity:  99.50%
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P4094
CAS No.: 1052692-86-0
Synonyms: Cardiac targeting peptide
Target:  

Peptides

Research Areas:  

Cardiovascular Disease

CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-145793
CAS No.: 2328129-27-5
Purity:  ≥98.0%
FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-145799
CAS No.: 1857341-90-2
Purity:  95.98%
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-113011
CAS No.: 1109-28-0
Purity:  ≥98.0%
Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P5623
CAS No.: 115136-25-9
Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29
RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-112772A
CAS No.: 917572-74-8
Purity:  ≥98.0%
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA-delivery to the liver.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-D1719A
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Cypate is a near-infrared fluorescent dye that belongs to the family of photosensitizers. Cypate has high photostability and optical properties, and is often used in near-infrared optical imaging, as well as optical imaging, tumor marking, and drug delivery. In addition, Cypate is also used as a molecular probe and combined with targeting molecules (such as CBT or small interfering RNA) to achieve efficient detection and imaging of specific cells or tissues .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-145799A
Purity:  98.03%
Target:  

Liposome

Research Areas:  

Cancer

5A2-SC8 TFA is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 TFA LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
loading...
    loading...
Cat. No.: HY-131119
CAS No.: 3700-67-2
Purity:  ≥98.0%
Synonyms: Dioctadecyldimethylammonium bromide; DODAB
Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.
loading...
    loading...
Cat. No.: HY-W075517
CAS No.: 59061-53-9
Synonyms: 2-Methylimidazole zinc salt
Target:  

Caspase Pyroptosis MOFs

Research Areas:  

Cancer

ZIF-8 (2-Methylimidazole zinc salt) is a caspase-1/Gasdermin D activator and a pH- and stimulus-responsive inducer of drug release, which serves as a highly efficient drug delivery carrier. ZIF-8 is a metal-organic framework (MOF). ZIF-8 activates the caspase-1/Gasdermin D-dependent pyroptosis pathway, induces pyroptosis, necrosis and immunogenic cell death, initiates in situ anti-tumor immunity, reprograms the immunosuppressive tumor microenvironment and inhibits tumor proliferation. ZIF-8 is applicable to related research on multiple cancers including colorectal cancer and breast cancer .
loading...
    loading...
Cat. No.: HY-155882
CAS No.: 80506-64-5
Synonyms: mPEG750-NH2
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
loading...
    loading...
Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
loading...
    loading...
Cat. No.: HY-145795
CAS No.: 1883431-67-1
Purity:  ≥98.0%
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
loading...
    loading...
Cat. No.: HY-P5284
CAS No.: 1613231-49-4
Target:  

Peptides

Research Areas:  

Others

RALA peptide is a cationic amphiphilic delivery agent targeting cell membranes, which forms nanoparticles through electrostatic interactions with anionic drugs. RALA peptide has pH-responsive binding properties, which can enhance the α-helical conformation in an acidic environment and destroy the endosomal membrane, promote the release of drugs into the cytoplasm, and exert efficient intracellular delivery activity. RALA peptide can be used in cancer research (enhancing the activity of bisphosphonates against prostate cancer and breast cancer cells) and bone tissue engineering (promoting osteoblast collagen deposition and extracellular matrix mineralization) .
loading...
    loading...
Cat. No.: HY-150229
CAS No.: 2803699-70-7
Purity:  98.84%
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .
loading...
    loading...
Cat. No.: HY-145396
Purity:  ≥98.0%
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .
loading...
    loading...
Cat. No.: HY-P4086
CAS No.: 1678417-57-6
Target:  

RABV nAChR

Research Areas:  

Neurological Disease Cancer

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to
nAChR
on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .
loading...
    loading...
Cat. No.: HY-P10644A
Target:  

Peptides

Research Areas:  

Cancer

CPP9 TFA is a small, amphipathic, cyclic cell penetrating peptide (CPP). CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome. CPP9 TFA can be used for intracellular delivery of therapeutic agents and chemical probes .
loading...
    loading...
Cat. No.: HY-P10649
CAS No.: 1831064-62-0
Target:  

Peptides

Research Areas:  

Cancer

CPP12 is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 can be used for the intracellular delivery of drugs and chemical probes .
loading...
    loading...