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FANCM MM2 domain

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P11842
    Ac-HFKLYWPPFLGS-NH2

    		DNA/RNA Synthesis Cancer
    Ac-HFKLYWPPFLGS-NH2 is a RMI1/2 heterodimer inhibitor with an IC50 of 99 nM and antiproliferative activity. Ac-HFKLYWPPFLGS-NH2 binds competitively at the FANCM-RMI interaction interface, mimics native FANCM MM2 domain hydrophobic interactions, and adopts a unique binding pose with additional protein interactions. Ac-HFKLYWPPFLGS-NH2 induces antiproliferative effects in ALT-positive osteosarcoma cells. Ac-HFKLYWPPFLGS-NH2 shows limited stability toward α-chymotrypsin-mediated enzymatic degradation in vitro. Ac-HFKLYWPPFLGS-NH2 lacks inherent cell permeability, requiring conjugation to a cell-penetrating peptide for intracellular delivery. Ac-HFKLYWPPFLGS-NH2 can be used for the research of ALT-positive osteosarcoma .
    Ac-HFKLYWPPFLGS-NH2

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