28 Results for "

Furin

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "Furin" in MCE Product Catalog:

  • Targets Recommended:
7
7 Publications Verification
Cat. No.: HY-P1028
CAS No.: 673202-67-0
Synonyms: Furin Inhibitor II
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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7
7 Publications Verification
Cat. No.: HY-P1028A
CAS No.: 958204-56-3
Synonyms: Furin Inhibitor II TFA
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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3
3 Cited Publications
Cat. No.: HY-147140
CAS No.: 2387633-15-8
Purity:  98.45%
Target:  

Furin

Research Areas:  

Inflammation/Immunology

BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .
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2
2 Cited Publications
Cat. No.: HY-P78747
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Furin; Subtilisin-Like Proprotein Convertase 1; Prev. PCSK3; Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein); Prev. PACE; Furin (Paired Basic Amino Acid Cleaving Enzyme); Prev. FUR; Proprotein Convertase Subtilisin/Ke
Species:  
Source:  
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Cat. No.: HY-P0133
CAS No.: 143413-47-2
Synonyms: Nona-L-arginine; Peptide R9
Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model .
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Cat. No.: HY-P2469
CAS No.: 1816939-52-2
Synonyms: BNP-45, mouse
Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities .
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Cat. No.: HY-150737
CAS No.: 2417283-44-2
Purity:  95.08%
Target:  

SARS-CoV

Research Areas:  

Infection

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity .
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Cat. No.: HY-110147B
Purity:  ≥99.0%
Target:  

Furin

Research Areas:  

Infection

SSM-3 tetraTFA hydrate is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA hydrate uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA hydrate can be used in the research of anthrax and avian influenza .
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Cat. No.: HY-P4548
CAS No.: 136132-77-9
Synonyms: Boc-RVRR-AMC
Target:  

Furin

Research Areas:  

Others

Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
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Cat. No.: HY-P4349A
CAS No.: 1255501-99-5
Research Areas:  

Others

Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide, and a fluorescent substrate. Pyr-Arg-Thr-Lys-Arg-AMC TFA can be used to detect the activity of specific proteases, such as Furin, Trypsin, and Thrombin .
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Cat. No.: HY-P5272
CAS No.: 112844-49-2
Target:  

Bacterial

Research Areas:  

Inflammation/Immunology

Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
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Cat. No.: HY-P3797
CAS No.: 174838-79-0
Target:  

Furin

Research Areas:  

Cancer

Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .
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Cat. No.: HY-163738
Target:  

Furin SARS-CoV

Research Areas:  

Infection

Furin-IN-2 (compound P3) is a potent inhibitor of furin, with the IC50 of 35 μM. Furin-IN-2 shows antiviral activity .
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Cat. No.: HY-P11413
CAS No.: 139446-70-1
PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-P4349
CAS No.: 155575-02-3
Research Areas:  

Others

Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide, and a fluorescent substrate. Pyr-Arg-Thr-Lys-Arg-AMC can be used to detect the activity of specific proteases, such as Furin, Trypsin, and Thrombin .
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Cat. No.: HY-RS05148
Research Areas:  

Others

FURIN Human Pre-designed siRNA Set A contains three designed siRNAs for FURIN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19197
Research Areas:  

Others

Furin Mouse Pre-designed siRNA Set A contains three designed siRNAs for Furin gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS25685
Research Areas:  

Others

Furin Rat Pre-designed siRNA Set A contains three designed siRNAs for Furin gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-110147A
CAS No.: 2320930-10-5
Target:  

Furin

Research Areas:  

Infection

SSM-3 tetraTFA is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA can be used in the research of anthrax and avian influenza .
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Cat. No.: HY-180145
CAS No.: 3080672-14-3
Target:  

Furin Influenza Virus

Research Areas:  

Infection

Furin-IN-3 is a non-peptidic furin inhibitor with a dichlorobiphenyl-derived core, with a Ki value of 1.67 nM for furin inhibition and a Ki value of 278 nM for proprotein convertase PC7 inhibition. Furin-IN-3 can be used in the research of influenza A virus infection (H7N7 strain SC35M) .
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