1. Anti-infection
  2. SARS-CoV
  3. MI-1851

MI-1851 

Cat. No.: HY-150737
Handling Instructions

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity.

For research use only. We do not sell to patients.

MI-1851 Chemical Structure

MI-1851 Chemical Structure

CAS No. : 2417283-44-2

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Description

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2].

In Vitro

MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner[1].
MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold[2].
MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo
Animal Model: Rats[3]
Dosage: 2.5 mg/kg
Administration: Intravenous injection; once
Result: The pharmacokinetic parameters of MI-1851 (compound 8)
Parameter MI-1851 (compound 8)
t1/2 1.6 h
total body clearance 273 mL/(h•kg)
Cmax 3156 ng/mL
Molecular Weight

767.88

Formula

C34H53N15O6

CAS No.
SMILES

NC(NCC1=CC=C(C=C1)CC(N[[email protected]](C(N[[email protected]](C(N[[email protected]](C(NCC2=CC=C(C=C2)C(N)=N)=O)CCONC(N)=N)=O)C(C)(C)C)=O)CCONC(N)=N)=O)=N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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MI-1851
Cat. No.:
HY-150737
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