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German cockroaches

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By Targets:	Environmental Pollutants (1) Insecticide (2) nAChR (1) Parasite (1) Phosphodiesterase (PDE) (1) Sex Pheromone (1) Sodium Channel (1)
By Research Areas:	Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0827

Dinotefuran 4 Publications Verification MTI-446	Environmental Pollutants Parasite nAChR	Infection Cardiovascular Disease
Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [ ³H]epibatidine in the neural cord membrane of American cockroach with an IC₅₀ of 890 nM and to [ ³H]α-bungarotoxin with an IC₅₀ of 36.1 μM. Dinotefuran exhibits knockdown activity (KD₅₀=0.351 nmol/g) and lethal activity (LD₅₀=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks .

HY-P2936A

Sphingomyelin phosphodiesterase, Bacillus cereus	Insecticide Phosphodiesterase (PDE)	Infection Neurological Disease Inflammation/Immunology
Sphingomyelin phosphodiesterase, Bacillus cereus is a sphingomyelin hydrolase and Insecticide. Sphingomyelin phosphodiesterase, Bacillus cereus catalyzes the decomposition of sphingomyelin into ceramide and phosphorylcholine. Sphingomyelin phosphodiesterase, Bacillus cereus causes rapid paralysis and death in injected insects, including German cockroaches and black cutworms. Sphingomyelin phosphodiesterase, Bacillus cereus reduces H₂O₂ production. Sphingomyelin phosphodiesterase, Bacillus cereus can be used in studies related to sepsis and endophthalmitis .

HY-W561401

Blattellaquinone	Sex Pheromone	Endocrinology
Blattellaquinone is a sex pheromone isolated from German cockroaches .

HY-P5162

Dc1a	Sodium Channel	Inflammation/Immunology
Dc1a potently promotes opening of the German cockroach Na_v channel (BgNa_v1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .

HY-N18035

Spinosyn K	Insecticide	Infection
Spinosyn K is an insecticide found in the actinomycete Saccharopolyspora spinosa. Spinosyn K shows strong insecticidal activity .

Cat. No.	Product Name	Target	Research Area

HY-P5162

Dc1a	Sodium Channel	Inflammation/Immunology
Dc1a potently promotes opening of the German cockroach Na_v channel (BgNa_v1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .

Blattellaquinone	Quinones Structural Classification Animals Benzene Quinones Source Classification	Sex Pheromone
Blattellaquinone is a sex pheromone isolated from German cockroaches .

Spinosyn K	Structural Classification Natural Products Microorganisms Source Classification	Insecticide
Spinosyn K is an insecticide found in the actinomycete Saccharopolyspora spinosa. Spinosyn K shows strong insecticidal activity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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German cockroaches

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