165252-70-0
Chemical Structure
Dinotefuran
Synonym(s): MTI-446
- CAS No.: 165252-70-0
- Formula:C7H14N4O3
- Molecular Weight:202.21
IUPAC Name: (E)-1-methyl-3-nitro-2-((tetrahydrofuran-3-yl)methyl)guanidine
InChIKey: YKBZOVFACRVRJN-UHFFFAOYSA-N
SMILES: O=[N+](N/C(NC)=N/CC1COCC1)[O-]
Biological Activity: Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Dinotefuran | 99.74% | Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dinotefuran (Standard) | ≥98% | Dinotefuran (Standard) is the analytical standard of Dinotefuran. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dinotefuran-d3 | Dinotefuran-d3 is the deuterium labeled Dinotefuran. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Mori K, et al. Interaction of dinotefuran and its analogues with nicotinic acetylcholine receptors of cockroach nerve cords. Pest Manag Sci. 2002 Feb;58(2):190-6. [Content Brief]
- [2]. Liu T, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164. [Content Brief]
- [3]. Tanaka T, et al. Reproductive and neurobehavioral effects of dinotefuran in an F1 -generation toxicity study in mice. Birth Defects Res. 2023 Oct 1;115(16):1534-1555. [Content Brief]
