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Results for "

Ghrelin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GHSR (36) Acyltransferase (2) Adrenergic Receptor (1) Amino Acid Derivatives (1) AMPK (1) Bacterial (2) Biochemical Assay Reagents (1) Calcium Channel (1) Endogenous Metabolite (15) Environmental Pollutants (1) Free Fatty Acid Receptor (1) GHR (1) GPR35 (1) GPR39 (1) IFNAR (1) IGF-1R (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Neuropeptide Y Receptor (2) Neurotensin Receptor (1) NF-κB (1) Phosphatase (1) Phospholipase (2) Reference Standards (5) Somatostatin Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Endocrinology (9) Infection (2) Inflammation/Immunology (5) Metabolic Disease (38) Neurological Disease (12)

By Targets:

GHSR (36)

Acyltransferase (2)

Adrenergic Receptor (1)

Amino Acid Derivatives (1)

AMPK (1)

Bacterial (2)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Endogenous Metabolite (15)

Environmental Pollutants (1)

Free Fatty Acid Receptor (1)

GHR (1)

GPR35 (1)

GPR39 (1)

IFNAR (1)

IGF-1R (1)

Insulin Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Neuropeptide Y Receptor (2)

Neurotensin Receptor (1)

NF-κB (1)

Phosphatase (1)

Phospholipase (2)

Reference Standards (5)

Somatostatin Receptor (1)

TNF Receptor (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (5)

Endocrinology (9)

Infection (2)

Inflammation/Immunology (5)

Metabolic Disease (38)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: GHSR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0337

L-Cysteine Maximum Cited Publications 12 Publications Verification Cysteine	Environmental Pollutants Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent .

HY-Y0337A

L-Cysteine hydrochloride Maximum Cited Publications 12 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses *ghrelin* and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-14734

Anamorelin 5+ Cited Publications RC-1291; ONO-7643	GHSR	Endocrinology Cancer
Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC₅₀ of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia .

HY-W016715

L-Cysteine hydrochloride hydrate Maximum Cited Publications 12 Publications Verification	Endogenous Metabolite NF-κB Insulin Receptor	Neurological Disease Metabolic Disease
L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .

HY-12584

PF-5190457 PF-05190457	GHSR	Metabolic Disease Endocrinology
PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pK_i of 8.36 .

HY-Y0337S5

L-Cysteine-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Cysteine-d₃ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-P0232

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Amino Acid Derivatives	Inflammation/Immunology Cancer
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-14734A

Anamorelin hydrochloride 5+ Cited Publications RC-1291 hydrochloride; ONO-7643 hydrochloride	GHSR	Endocrinology Cancer
Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC₅₀ of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia .

HY-19884B

Relamorelin TFA 1 Publications Verification RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-P5645

LEAP-2 1 Publications Verification Human liver expressed antimicrobial peptide-2	GHSR Interleukin Related IFNAR TNF Receptor Bacterial	Infection Metabolic Disease Inflammation/Immunology
LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC₅₀ of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection .

HY-Y0337S2

L-Cysteine-3-13C Cysteine-¹³C	Endogenous Metabolite	Metabolic Disease
L-Cysteine-3- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-Y0337S

L-Cysteine-13C3,15N 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-114610

13Z,16Z-Docosadienoic acid	Endogenous Metabolite Free Fatty Acid Receptor Bacterial	Infection Cancer
13Z,16Z-Docosadienoic acid is a GPR120 agonist with bactericidal activity. 13Z,16Z-Docosadienoic acid serves as a potential biomarker for canine mammary tumors. 13Z,16Z-Docosadienoic acid is used in the research of bacterial infections, Lyme disease, Graves' disease and mammary tumors .

HY-14903

Ulimorelin TZP-101	GHSR Adrenergic Receptor	Metabolic Disease
Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC₅₀ of 29 nM and a K_i of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition .

HY-13964

YIL781	GHSR	Metabolic Disease
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-P0231

AZP-531 2 Publications Verification	GHSR	Metabolic Disease Endocrinology
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P1366

des-Gln14-Ghrelin 1 Publications Verification	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-16639

ML314	GPR35 Neurotensin Receptor	Neurological Disease Endocrinology
ML314 is a potent, BBB-penetrant and β-arrestin biased molecule agonist of NTR1 (EC₅₀ = 1.9 μM). ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions .

HY-Y0337R

L-Cysteine (Standard) 1 Publications Verification Cysteine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (Standard) is the analytical standard of L-Cysteine. This product is intended for research and analytical applications. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-171962A

KARI 201 hydrochloride	Phospholipase GHSR	Neurological Disease
KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC₅₀ of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease .

HY-P1212

Cortistatin 14 (mouse, rat) CST-14 (mouse, rat)	Somatostatin Receptor	Neurological Disease
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-Y0337S4

L-Cysteine-13C3 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹³C₃ is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-103479

GOAT-IN-1	Acyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-13964A

YIL781 hydrochloride	GHSR	Metabolic Disease
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-N12348

Emoghrelin	GHSR	Others
Emoghrelin, isolated from? Heshouwu Polygonum multiflorum, stimulates growth hormone secretion via activation of the ghrelin receptor .

HY-P11291A

NNC0165-1273 TFA	Neuropeptide Y Receptor	Metabolic Disease
NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291). NNC0165-1273 is an analog of gut hormone peptide YY (PYY_3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research .

HY-116625

PF-04628935	GHSR	Neurological Disease
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC₅₀ of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research .

HY-Y0337S1

L-Cysteine-15N 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹⁵N is the ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-Y0337S3

L-Cysteine-1-13C	Endogenous Metabolite	Metabolic Disease
L-Cysteine-1- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-145364

Ghrelin receptor full agonist-2	GHSR	Metabolic Disease
Ghrelin receptor full agonist-2 (compound 12j) is a highly potent Ghrelin receptor full agonist.

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-171962

KARI 201	Phospholipase GHSR	Neurological Disease
KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC₅₀ of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease .

HY-113906

GSK1614343	GHSR	Metabolic Disease
GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC₅₀ value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models .

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-111232

GSK894281	GHSR	Metabolic Disease
GSK894281 is an orally active and highly potent ghrelin receptor full agonist with a pEC₅₀ of <4.9 at the human motilin receptor. GSK894281 effectively enters the CNS. GSK894281 has the potential for constipation or to assist in emptying the colon prior to colonoscopy or colon surgery research .

HY-P1306

Obestatin(rat)	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P1421A

Obestatin(human) TFA	GPR39	Metabolic Disease
Obestatin(human) TFA is an endogenous peptide derived from the same prepropeptide as ghrelin. Obestatin(human) suppresses food intake and reduce body weight-gain in rats.

HY-129207

JMV 3002	GHSR	Endocrinology
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC₅₀ value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.

HY-Y0337S6

L-Cysteine-d2 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Cysteine-d₂ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-137061

AZ-GHS-22	GHSR	Metabolic Disease
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC₅₀=0.77 nM) .

HY-P1366A

*des-Gln14-Ghrelin* TFA**	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P1432

K-(D-1-Nal)-FwLL-NH2	GHSR	Metabolic Disease
K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC₅₀=3.4 nM, K_i=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity .

HY-19454

CP-464709	GHSR	Cardiovascular Disease
CP-464709 is a *Ghrelin* receptor agonist that can penetrate the blood-brain barrier. CP-464709 causes an increase in blood pressure by activating pre sympathetic neurons in the spinal cord. CP-464709 causes biphasic blood pressure response when administered intravenously, while intrathecal administration only causes pressor. CP-464709 can be used for research on cardiovascular conditions .

HY-P1306A

Obestatin(rat) TFA	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-Y0337AR

L-Cysteine hydrochloride (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

HY-P10673

KwFwLL-NH2	GHSR	Metabolic Disease
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM) .

HY-115272

GSK894490A	GHSR	Neurological Disease
GSK894490A is a non-peptide ghrelin receptor agonist .

HY-P1432A

K-(D-1-Nal)-FwLL-NH2 TFA	GHSR	Cancer
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

HY-148869A

Hexanoyl-coenzyme A triammonium 06:0 Coenzyme A triammonium	Biochemical Assay Reagents	Metabolic Disease
Hexanoyl-Coenzyme A triammonium (06:0 Coenzyme A) is a medium-chain fatty acyl CoA that is an acyl donor substrate for ghrelin O-acyltransferase (GOAT) .

Cat. No.	Product Name	Target	Research Area