5875-49-0
Chemical Structure
Meranzin hydrate
- CAS 番号: 5875-49-0
- Formula:C15H18O5
- Molecular Weight:278.30
IUPAC Name: (S)-8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
InChIKey: KGGUASRIGLRPAX-LBPRGKRZSA-N
SMILES: CC(C)(O)[C@@H](O)CC1=C(O2)C(C=CC2=O)=CC=C1OC
Biological Activity: Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder[1][2].
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Meranzin hydrate | 99.89% | Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder. | ||||||||||||||||||||
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Meranzin hydrate (Standard) | ≥98% | Meranzin hydrate (Standard) is the analytical standard of Meranzin hydrate (HY-N3297). This product is intended for research and analytical applications. Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder. | ||||||||||||||||||||
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Similarity Score 0.87
HY-N1058Yuehgesin C -
Similarity Score 0.84
HY-N7037Osthol hydrate -
Similarity Score 0.82
HY-N2910Auraptenol -
Similarity Score 0.81
HY-N3467Isomexoticin -
Similarity Score 0.81
HY-N7689Mexoticin -
Similarity Score 0.80
HY-N0080Ulopterol -
Similarity Score 0.78
HY-N3298RMeranzin (Standard) -
Similarity Score 0.77
HY-N3468Isomerazin -
Similarity Score 0.74
HY-N0518Toddalolactone -
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References
- [1]. Liu YL, et al. Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry. Chinese journal of integrative medicine. 2023 Jun;29(6):490-499. [Content Brief]
- [2]. Liu X, et al. Meranzin hydrate elicits antidepressant effects and restores reward circuitry. Behavioural brain research. 2021 Feb 01;398:112898. [Content Brief]
