5875-49-0
5875-49-0
Chemical Structure
Meranzin hydrate
- CAS No.: 5875-49-0
- Formula:C15H18O5
- Molecular Weight:278.30
IUPAC Name: (S)-8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
InChIKey: KGGUASRIGLRPAX-LBPRGKRZSA-N
SMILES: CC(C)(O)[C@@H](O)CC1=C(O2)C(C=CC2=O)=CC=C1OC
Biological Activity: Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Meranzin hydrate | 99.89% | Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Meranzin hydrate (Standard) | ≥98% | Meranzin hydrate (Standard) is the analytical standard of Meranzin hydrate (HY-N3297). This product is intended for research and analytical applications. Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ulopterol | Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Toddalolactone | 99.97% | Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Yuehgesin C | Yuehgesin C is a Coumarins product that can be isolated from the herbs of Murraya paniculata. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ent-Toddalolactone | ent-Toddalolactone is a natural compound with anti-inflammatory and anticancer activities. Ent-Toddalolactone has shown inhibitory effects on phosphodiesterase-4 (PDE4) in vitro and is a potential drug target for inhibiting asthma and chronic obstructive pulmonary disease. The activity of ent-Toddalolactone is related to its unique chemical structure, and some of its derivatives showed IC50 values below 10 μM in inhibition experiments, showing high biological activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Auraptenol | Auraptenol is a coumarin that can be isolated from the leaves of Murraya paniculata. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Meranzin (Standard) | ≥98% | Meranzin (Standard) is the analytical standard of Meranzin (HY-N3298). This product is intended for research and analytical applications. Meranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Isomexoticin | Isomexoticin is a natural coumarin. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Isomerazin | 99.84% | Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Osthol hydrate | Osthol hydrate is a natural product isolated from F. schottiana. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Mexoticin | 98.34% | Mexoticin is a naturally occurring coumarin that can be isolated from the leaves of Murraya omphalocarpa. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Liu YL, et al. Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry. Chinese journal of integrative medicine. 2023 Jun;29(6):490-499. [Content Brief]
- [2]. Liu X, et al. Meranzin hydrate elicits antidepressant effects and restores reward circuitry. Behavioural brain research. 2021 Feb 01;398:112898. [Content Brief]
