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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
731 Results for "
Glycans
" in MedChemExpress (MCE) Product Catalog:
Products (731)
731 Results for "Glycans" in MCE Product Catalog:
48
48 Publications Verification
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OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
2
2 Cited Publications
Cat. No.: HY-160109
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Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
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2
2 Cited Publications
Cat. No.: HY-P2929
CAS No.: 83534-39-8
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PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows .
2
2 Cited Publications
Cat. No.: HY-P2929C
CAS No.: 83534-39-8
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PNGase F (Lyophilized), a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F (Lyophilized) removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F (Lyophilized) can release N-glycans from glycoproteins in glycoanalytical workflows .
2
2 Cited Publications
Cat. No.: HY-P2929A
CAS No.: 83534-39-8
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PNGase F-Fast is a glycosidase that catalyzes the cleavage of internal glycosidic bonds in oligosaccharides. PNGase F-Fast removes almost all N-linked oligosaccharides from glycoproteins. PNGase F-Fast can release N-glycans from glycoproteins in the sugar analysis workflow. The cleavage site is: the glycosidic bond between the innermost N-acetylglucosamine and asparagine. PNGase F-Fast is an improved reagent that allows for rapid deglycosylation of antibodies and antibody fusions within minutes .
1
1 Cited Publications
Cat. No.: HY-W854445
CAS No.: 80081-06-7
1
1 Cited Publications
Cat. No.: HY-W015798
CAS No.: 4781-83-3
1
1 Cited Publications
Cat. No.: HY-W039924
CAS No.: 361154-23-6
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N-Azidoacetylmannosamine is an azide-labeled sugar that can be metabolically incorporated into glycoproteins. N-Azidoacetylmannosamine can then react with alkynes or phosphines that are linked to fluorescent or biotin tags for visualization or capture of the glycoproteins. N-Azidoacetylmannosamine can be used for studying glycan structures and functions in vivo .
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1
1 Cited Publications
Cat. No.: HY-KE7057
O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.
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CMP-SiaNAz (CMP-NeuNAz) sodium is a sialic acid nucleotide sugar derivative. CMP-SiaNAz sodium is integrated into the glycosidic chain through the action of STs in the Golgi apparatus, forming SiaNAz substances. CMP-SiaNAz sodium can serve as a substrate for bacterial-derived sialic acid transferases and is used for chemical enzymatic labeling and imaging of cell surface glycosides .
1
1 Cited Publications
Cat. No.: HY-163121
CAS No.: 1096144-06-7
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PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease .
Cat. No.: HY-158482
Synonyms: Mannose-3 N-linked oligosaccharide; Oligomannose 3 glycan
Cat. No.: HY-W017873
CAS No.: 35661-51-9
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9-Fluorenylmethyl carbazate is used as a fluorophore reagent for a fluorimetric detection of glycans .
Cat. No.: HY-N10531
CAS No.: 56570-03-7
Synonyms: Lewis a
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Cat. No.: HY-N10629
CAS No.: 84808-02-6
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A2G0 Glycan is a glycan, and can be used for labeling and modification of proteins.
Cat. No.: HY-N10626
CAS No.: 125139-41-5
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Cat. No.: HY-158485
CAS No.: 66091-47-2
Synonyms: Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan
Cat. No.: HY-158543
Synonyms: Mannose-9 N-linked oligosaccharide; Oligomannose 9 glycan
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
