M5 glycan (Man5)
M5 glycan (Man5) (Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan) is an N-linked glycan on glycoproteins on glycoproteins. M5 glycan (Man5) enhances antibody-dependent cell-mediated cytotoxicity and reduces complement-dependent cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 66091-47-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
When the proportion of M5 glycan (Man5) on mAb1 reaches 62%, 78% or 86%, it exhibits 5- to 7-fold higher ADCC activity against WIL2-S cells than complex fucosylated mAb1[1].
When present on mAb1 at levels of 62%, 78%, or 86%, M5 glycan (Man5) reduces the CDC activity against WIL2-S cells by 50% compared to fucosylated complex-type mAb1[1].
When the proportion of M5 glycan (Man5) on mAb1 reaches 62%, 78% or 86%, its binding affinity to FcγRIA is comparable to that of fucosylated complex-type mAb1, while its binding affinities to FcγRIIA and FcγRIIB are reduced, and its binding affinities to FcγRIIIA allotypes are increased by 4-8 folds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 66091-47-2
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Synonyms
Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yu M, et al. Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans. mAbs. 2012;4(4):475-87. [Content Brief]
[2]. Jiménez-Castells C, et al. Development of a multifunctional aminoxy-based fluorescent linker for glycan immobilization and analysis. Glycobiology. 2016 Dec;26(12):1297-1307. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
M5 glycan (Man5) Related Classifications
HY-158485 Related Classifications
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- M5 glycan (Man5)
- 66091-47-2
- Mannose-5 N-linked oligosaccharide
- Oligomannose 5 glycan
- Biochemical Assay Reagents
- b-lymphoma
- FcγRIIA H131
- antibody-dependent cell-mediated cytotoxicity
- complement-dependent cytotoxicity
- FcγRIIB
- FcγRIIIA F158
- FcγRIIIA V158
- WIL2-S cells
- Aspergillus saitoi
- FcγRIIA R131
- Inhibitor
- inhibitor
- inhibit