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Gram-negative uropathogenic bacteria

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Aaptamine
Aaptamine
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Cat. No.: HY-N4225
CAS No.: 85547-22-4
Category:  

Alkaloids Animals Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology

Target:  

Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB

Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .
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