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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
HES1
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "HES1" in MCE Product Catalog:
6
Target:
Research Areas:
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers [1] .
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2 Cited Publications
Category:
Vaccaria segetalis (Neck.) Garcke Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae
Target:
1
1 Cited Publications
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity [1].
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1 Cited Publications
Cat. No.: HY-P80155
Synonyms: bHLHb39 antibody;
C-HAIRY1 antibody;
Class B basic helix-loop-helix protein 39 antibody;
FLJ20408 antibody;
Hairy and enhancer of split 1 antibody;
Hairy homolog (Drosophila) antibody;
Hairy homolog antibody;
Hairy like antibody;
Hairy, Drosophila, homolog of antibody;
Hairy-like protein antibody;
HAIRY1 antibody;
HES-1 antibody;
HES1_HUMAN antibody;
HHL antibody;
HL antibody;
HRY antibody;
MGC129109 antibody;
OTTHUMP00000209031 antibody;
RHL antibody;
Transcription factor HES-1 antibody
Cat. No.: HY-N2740
CAS No.: 221257-06-3
Target:
Cat. No.: HY-RS06134
Target:
Research Areas:
HES1 Human Pre-designed siRNA Set A contains three designed siRNAs for HES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N3393
CAS No.: 221289-31-2
Target:
Cat. No.: HY-RS17070
Target:
Research Areas:
Hes1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hes1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-124484
CAS No.: 2234271-86-2
JI130 (JI051 derivative ) is a stabilizer for the Hes1-PHB2 interaction. JI130 inhibits the ability of Hes1 to repress transcription. JI130 significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for managing pancreatic cancer [1].
Cat. No.: HY-164410
CAS No.: 1585217-40-8
MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC [1].
Cat. No.: HY-RS23514
Target:
Research Areas:
Hes1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hes1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181975
CAS No.: 956181-19-4
ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research [1].
Cat. No.: HY-N13201
CAS No.: 66583-59-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
