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Results for "

HES1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

4

Natural
Products

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19369
    L-685458
    Maximum Cited Publications
    6 Publications Verification

    L-685,458

    		 γ-secretase Apoptosis Neurological Disease Cancer
    L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers [1] .
    L-685458
  • HY-117113
    JI051
    1 Publications Verification

    		 Notch Cancer
    JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity [1].
    JI051
  • HY-N2740
    Agalloside

    		Sirtuin Neurological Disease
    Agalloside is a neural stem cell differentiation activator that binds to Hes1, and it is found in Aquilaria agallocha. Agalloside promotes the differentiation of neural stem cells and increases the number of neurons. Agalloside can be used in studies related to neural stem cell differentiation [1].
    Agalloside
  • HY-RS06134
    HES1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HES1 Human Pre-designed siRNA Set A contains three designed siRNAs for HES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HES1 Human Pre-designed siRNA Set A
    HES1 Human Pre-designed siRNA Set A
  • HY-N3393
    Lethedioside A

    		β-catenin Inflammation/Immunology
    Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells [1] .
    Lethedioside A
  • HY-107245
    Segetalin B
    2 Publications Verification

    		 Estrogen Receptor/ERR Sirtuin RUNX Metabolic Disease
    Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) [1] .
    Segetalin B
  • HY-RS17070
    Hes1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hes1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hes1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hes1 Mouse Pre-designed siRNA Set A
    Hes1 Mouse Pre-designed siRNA Set A
  • HY-124484
    JI130

    		Notch Cancer
    JI130 (JI051 derivative ) is a stabilizer for the Hes1-PHB2 interaction. JI130 inhibits the ability of Hes1 to repress transcription. JI130 significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for managing pancreatic cancer [1].
    JI130
  • HY-164410
    MO-I-1100

    		Notch Cancer
    MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC [1].
    MO-I-1100
  • HY-RS23514
    Hes1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hes1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hes1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hes1 Rat Pre-designed siRNA Set A
    Hes1 Rat Pre-designed siRNA Set A
  • HY-181975
    ATOX1-IN-1

    		Notch Cancer
    ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research [1].
    ATOX1-IN-1
  • HY-N13201
    12-Deoxyphorbol 13-palmitate

    		Apoptosis CDK Cancer
    12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2 [1] .
    12-Deoxyphorbol 13-palmitate

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