956181-19-4
Chemical Structure
ATOX1-IN-1
- CAS No.: 956181-19-4
- Formula:C33H26N2O6
- Molecular Weight:546.57
InChIKey: NZFZTQSDHIJFNM-NDEPHWFRSA-N
SMILES: O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(OC3=CC=C(C(C=CC=C4)=C4C(O5)=O)C5=C3C)=O)OCC6=CC=CC=C6
Biological Activity: ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research[1].
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ATOX1-IN-1 | ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research. | |||||||||||||||||||||
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