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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
HSP70-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "HSP70-IN-1" in MCE Product Catalog:
1
1 Cited Publications
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
Cat. No.: HY-170944
BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with Kds of 33.10 μM, 27.90 μM, and 33.80 μM, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 μM. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity .
Cat. No.: HY-W099504
CAS No.: 111-70-6
Synonyms: n-Heptyl alcohol
Cat. No.: HY-178462
Target:
Research Areas:
Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1 .
Cat. No.: HY-W099504S
CAS No.: 194793-95-8
Synonyms: n-Heptyl alcohol-d15
Cat. No.: HY-P10635
CAS No.: 403668-80-4
Target:
Research Areas:
Cat. No.: HY-W099504S1
CAS No.: 1219804-99-5
Synonyms: n-Heptyl alcohol-d7
Cat. No.: HY-181148
CAS No.: 952738-81-7
Research Areas:
HSP70 ligand 1, a HSP70 ligand, is a ligand for the target protein of PROTAC. HSP70 ligand 1 can be used to synthesize PROTAC HSP70 Degrader-1 (HY-181147) .
Cat. No.: HY-181147
PROTAC HSP70 Degrader-1 (compound C4) is a cytosolic HSP70 PROTAC degrader that can engage CRBN to form a ternary complex. PROTAC HSP70 Degrader-1 mediates ubiquitination and proteasomal degradation of cytosolic HSP70. PROTAC HSP70 Degrader-1 exhibits cytotoxic activity against cancer cells, suppressing tumor cell proliferation and inducing apoptosis in combination with DTHIB. PROTAC HSP70 Degrader-1 can be used for the research of colon cancer and leukemia .
Cat. No.: HY-W099504S2
CAS No.: 38007-42-0
Synonyms: n-Heptyl alcohol-d1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
