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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
251 Results for "
High-throughput screening
" in MedChemExpress (MCE) Product Catalog:
Products (251)
251 Results for "High-throughput screening" in MCE Product Catalog:
Cat. No.: HY-D1581
CAS No.: 878674-84-1
Cat. No.: HY-160250
CAS No.: 2097024-37-6
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UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators .
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AHMT is an aldehyde-specific and aldehyde-reactive colorimetric detection reagent. AHMT detects the formation of Phenylacetaldehyde in high-throughput screening for engineered anti-Markovnikov oxidation activity. AHMT serves as a formaldehyde detection reagent to detect formaldehyde produced in the Methanethiol oxidase reaction .
Cat. No.: HY-136797
CAS No.: 1622060-51-8
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BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.
Cat. No.: HY-160426
CAS No.: 2270984-21-7
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Gcase activator 3 is a β-glucocerebrosidase (GCase) activator with an EC50 of 1.49 μM. By binding to the allosteric site of GCase, Gcase activator 3 partially stabilizes GCase and enhances its activity. Gcase activator 3 can be conjugated with fluorophores to form fluorescent probes, which are used for high-throughput screening of GCase. Gcase activator 3 is applicable to research related to Gaucher's disease, Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy .
Cat. No.: HY-137115
CAS No.: 334658-24-1
BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs .
GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent.
Cat. No.: HY-P6299
CAS No.: 944792-75-0
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Cat. No.: HY-P10699
CAS No.: 487036-63-5
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Cat. No.: HY-D2983
CAS No.: 2310262-15-6
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AHMT (Standard) is the analytical standard of AHMT (HY-D0906). This product is intended for research and analytical applications. AHMT is an aldehyde-specific and aldehyde-reactive colorimetric detection reagent. AHMT detects the formation of Phenylacetaldehyde in high-throughput screening for engineered anti-Markovnikov oxidation activity. AHMT serves as a formaldehyde detection reagent to detect formaldehyde produced in the Methanethiol oxidase reaction .
Cat. No.: HY-118012
CAS No.: 392237-10-4
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Flaviviruses-IN-1 is an inhibitor of several viruses belonging to the Flaviviridae family, with activity to inhibit viral infection. Flaviviruses-IN-1 is able to specifically inhibit multiple viruses of the Flaviviridae family. The mechanism of action of Flaviviruses-IN-1 is related to the modulation of the host cell immune response to viral infection. Flaviviruses-IN-1 was identified as a potential candidate compound in a high-throughput screening. Flaviviruses-IN-1 provides a new strategy for inhibiting infections caused by the Flaviviridae family .
Cat. No.: HY-135711
CAS No.: 1305116-69-1
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PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use .
Cat. No.: HY-123702
CAS No.: 660817-08-3
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CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .
Cat. No.: HY-L0087V
503,810 compounds
Life Chemicals Collection of small organic molecules for high-throughput screening currently contains 503,810 off-the-shelf products. The Collection is being permanently replenished with de novo designed products having optimal physicochemical parameters for drug discovery.
Cat. No.: HY-115585
CAS No.: 1026295-98-6
HDAC-IN-2 (Compound 6) is an inhibitor of histone deacetylase 4 (HDAC4). HDAC-IN-2 has affinity for Class IIa enzymes. HDAC-IN-2 is a useful research tool for high-throughput screening and follow-up chemistry .
Cat. No.: HY-184527
CAS No.: 1372609-54-5
Synonyms: 2-Chloro-4-nitrophenyl ferulate
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CNPF (2-Chloro-4-nitrophenyl ferulate) is a chromogenic substrate of Feruloyl esterase A (derived from Aspergillus niger). CNPF can be hydrolyzed by this enzyme to release the chromophore. CNPF has a superior signal-to-noise ratio and is suitable for high-throughput screening of feruloyl esterase .
Cat. No.: HY-181573
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TC8026 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), with an IC50 of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma .
Cat. No.: HY-L947
1,859 compounds
Built on druggable heterocyclic backbones with tunable electrophilic warheads (halogens, cyano groups), our electrophilic heterocyclic fragment library targets non-conserved cysteine/lysine residues and screens covalent ligands through an electrophile-first workflow. It generates high-quality dual-functional fragments for KRAS, BTK and other popular targets, supporting MS and DEL high-throughput screening to accelerate covalent drug lead discovery.
MCE Electrophilic Heterocyclic Fragment Library Built on druggable heterocyclic backbones with tunable electrophilic warheads (halogens, cyano groups), our electrophilic heterocyclic fragment library targets non-conserved cysteine/lysine residues and screens covalent ligands through an electrophile-first workflow. It generates high-quality dual-functional fragments for KRAS, BTK and other popular targets, supporting MS and DEL high-throughput screening to accelerate covalent drug lead discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
