GSPT1 degrader-15
Based on 1 Customer Validation
GSPT1 degrader-15 (Compound Lib-B-15O) is a potent and highly selective GSPT1 molecular gel degrader, with a DC50 of 154 nM. GSPT1 degrader-15 has almost no effect on the expression of other proteins. GSPT1 degrader-15 exhibits significant anti-proliferative activity against leukemia cells and lymphoma cells. GSPT1 degrader-15 can be used in leukemia and lymphoma research.
For research use only. We do not sell to patients.
- Purity: 95.05%
- CAS No.: 3060504-66-4
- Formula: C36H29N5O7S
- Molecular Weight:675.71
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | IC50 |
0.131 μM
Compound: Lib-B-15O; 15O
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Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
| MOLT-4 | IC50 |
0.175 μM
Compound: Lib-B-15O; 15O
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Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
| RS4-11 | IC50 |
0.007 μM
Compound: Lib-B-15O; 15O
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Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
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[PMID: 37390512] |
Chemical Information
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CAS No. 3060504-66-4
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Appearance Solid
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Molecular Weight 675.71
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Formula C36H29N5O7S
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Color White to off-white
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SMILES
O=C(NC1=O)CCC1N(C(C2=CC=C3)=O)CC2=C3C4=CC=CC=C4OCC(N/N=C/C5=CN(S(C6=CC=CC=C6)(=O)=O)C7=C5C=CC=C7)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (147.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4799 mL | 7.3996 mL | 14.7992 mL | 36.9981 mL |
| 5 mM | 0.2960 mL | 1.4799 mL | 2.9598 mL | 7.3996 mL | |
| 10 mM | 0.1480 mL | 0.7400 mL | 1.4799 mL | 3.6998 mL | |
| 15 mM | 0.0987 mL | 0.4933 mL | 0.9866 mL | 2.4665 mL | |
| 20 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8499 mL | |
| 25 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4799 mL | |
| 30 mM | 0.0493 mL | 0.2467 mL | 0.4933 mL | 1.2333 mL | |
| 40 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL | |
| 50 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7400 mL | |
| 60 mM | 0.0247 mL | 0.1233 mL | 0.2467 mL | 0.6166 mL | |
| 80 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL | |
| 100 mM | 0.0148 mL | 0.0740 mL | 0.1480 mL | 0.3700 mL |
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