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  4. GSPT1 degrader-15

GSPT1 degrader-15 (Compound Lib-B-15O) is a potent and highly selective GSPT1 molecular gel degrader, with a DC50 of 154 nM. GSPT1 degrader-15 has almost no effect on the expression of other proteins. GSPT1 degrader-15 exhibits significant anti-proliferative activity against leukemia cells and lymphoma cells. GSPT1 degrader-15 can be used in leukemia and lymphoma research.

For research use only. We do not sell to patients.

GSPT1 degrader-15

GSPT1 degrader-15 Chemical Structure

CAS No. : 3060504-66-4

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Based on 1 publication(s) in Google Scholar

GSPT1 degrader-15 Related Antibodies

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Description

GSPT1 degrader-15 (Compound Lib-B-15O) is a potent and highly selective GSPT1 molecular gel degrader, with a DC50 of 154 nM. GSPT1 degrader-15 has almost no effect on the expression of other proteins. GSPT1 degrader-15 exhibits significant anti-proliferative activity against leukemia cells and lymphoma cells. GSPT1 degrader-15 can be used in leukemia and lymphoma research[1].

Cellular Effect
Cell Line Type Value Description References
MM1.S IC50
0.131 μM
Compound: Lib-B-15O; 15O
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
MOLT-4 IC50
0.175 μM
Compound: Lib-B-15O; 15O
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
RS4-11 IC50
0.007 μM
Compound: Lib-B-15O; 15O
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue assay
[PMID: 37390512]
Molecular Weight

675.71

Formula

C36H29N5O7S
CAS No.
SMILES

O=C(NC1=O)CCC1N(C(C2=CC=C3)=O)CC2=C3C4=CC=CC=C4OCC(N/N=C/C5=CN(S(C6=CC=CC=C6)(=O)=O)C7=C5C=CC=C7)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSPT1 degrader-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSPT1 degrader-153060504-66-4Molecular GluesMolecular gluesCereblon(CRBN)GSPT1Targeted protein degradationRapid synthesisHigh-throughput screeningAcylhydrazone linkerProteomicsInhibitorinhibitorinhibit

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