2768029-03-2
2768029-03-2
Chemical Structure
TRPM5 agonist-1
- CAS No.: 2768029-03-2
- Formula:C11H7Cl2N3S2
- Molecular Weight:316.23
InChIKey: GFNMKESSHVFPQM-UHFFFAOYSA-N
SMILES: ClC1=CN=C(CNC2=CC3=C(C=C2Cl)C=NS3)S1
Biological Activity: TRPM5 agonist-1 is an orally active TRPM5 agonist with a pEC50 of 8.1. TRPM5 agonist-1 shows excellent selectivity (> 100-fold) versus related cation channels (TRPM8, TRPV1, TRPV4, TRPA1, TRPM4). TRPM5 agonist-1 exhibits locally acting stimulatory effect on gastrointestinal transit in mice. TRPM5 agonist-1 can be used for research on promoting gastric motility[1].
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TRPM5 agonist-1 | TRPM5 agonist-1 is an orally active TRPM5 agonist with a pEC50 of 8.1. TRPM5 agonist-1 shows excellent selectivity (> 100-fold) versus related cation channels (TRPM8, TRPV1, TRPV4, TRPA1, TRPM4). TRPM5 agonist-1 exhibits locally acting stimulatory effect on gastrointestinal transit in mice. TRPM5 agonist-1 can be used for research on promoting gastric motility. | |||||||||||||||||||||
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References
- [1]. Barilli A, et al. From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents. J Med Chem. 2021 May 13;64(9):5931-5955. [Content Brief]
Keywords
