1305116-69-1
Chemical Structure
PDE8B-IN-1
- CAS. Nr.: 1305116-69-1
- Formula:C14H18N8OS
- Molecular Weight:346.41
IUPAC Name: (R)-5-methyl-3-((4-(thiazol-2-ylmethyl)morpholin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
InChIKey: QGTJGTFOISKMAD-SNVBAGLBSA-N
SMILES: NC1=C(N=NN2C[C@H]3CN(CC4=NC=CS4)CCO3)C2=NC(C)=N1
Biological Activity: PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use[1].
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PDE8B-IN-1 | 99.91% | PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use. | ||||||||||||||||||||
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