334658-24-1
Chemical Structure
BODIPY-Cyclopamine
- CAS No.: 334658-24-1
- Formula:C49H70BF2N5O4
- Molecular Weight:841.92
IUPAC Name: 6-(3-(5,5-difluoro-7,9-dimethyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanamido)-N-(2-((3S,3'R,3a'S,6aS,6bS,6'S,7a'R,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethyl-1,2,3,3',3a',4,5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-
InChIKey: CQPRECBXTRAUSE-RYVGRFGLSA-N
SMILES: C[C@H]1[C@@]2(O[C@@](C[C@@H]3C)([H])[C@@]1([H])N(C3)CCNC(CCCCCNC(CCC4=CC=C(C=C(C(C)=C5)[N]6=C5C)[N-]4[B+3]6([F-])[F-])=O)=O)C(C)=C(C[C@@]7([H])[C@@]8([H])CC=C(C9)[C@@]7(CC[C@@H]9O)C)[C@@]8([H])CC2
Biological Activity: BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs[1].
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BODIPY-Cyclopamine | 98.91% | BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs. | ||||||||||||||||||||
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Keywords
